Seroatlas · Human Serome Atlas

PXDC1

PX domain-containing protein 1

Also known as: C6orf145, PXDC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TGL8
Gene: PXDC1
Ensembl: ENSG00000168994
Chromosome: 6
Canonical length: 231 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable phosphatidylinositol binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

231 residues, UniProt reviewed canonical sequence.

>Q5TGL8|PXDC1
     1  MASAVFEGTS LVNMFVRGCW VNGIRRLIVS RRGDEEEFFE IRTEWSDRSV LYLHRSLADL
    61  GRLWQRLRDA FPEDRSELAQ GPLRQGLVAI KEAHDIETRL NEVEKLLKTI ISMPCKYSRS
   121  EVVLTFFERS PLDQVLKNDN VHKIQPSFQS PVKISEIMRS NGFCLANTET IVIDHSIPNG
   181  RDQQLGVDPT EHLFENGSEF PSELEDGDDP AAYVTNLSYY HLVPFETDIW D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PXDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 214 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 214 nTPM
liver: 184 nTPM
choroid plexus: 83 nTPM
adipose tissue: 78 nTPM
breast: 60 nTPM
placenta: 58 nTPM

Single-cell type

extravillous trophoblasts: 194 nCPM
alveolar cells type 1: 118 nCPM
hepatocytes: 84 nCPM
breast secretory cells: 81 nCPM
lymphatic endothelial cells: 80 nCPM
syncytiotrophoblasts: 78 nCPM

Immune cell

memory B-cell: 1.2 nTPM
T-reg: 0.3 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 54 nTPM
medulla oblongata: 34 nTPM
spinal cord: 29 nTPM
midbrain: 27 nTPM
white matter: 27 nTPM
thalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.72
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

phosphatidylinositol binding

Protein domainsUniProt · Pfam · InterPro

PX domain superfamily
PX domain-containing protein 1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PXDC1 as an antibody target. Whether an autoantibody or antibody against PXDC1 could matter depends on whether native PXDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PXDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PXDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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