Seroatlas · Human Serome Atlas

PWWP4

Putative PWWP domain-containing DNA repair factor 4

Also known as: PWWP4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A494C071
Gene
PWWP4
Canonical length
2061 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PWWP4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

2061 residues, UniProt reviewed canonical sequence.

>A0A494C071|PWWP4
     1  MDSEYVLCSW KGRLWPAKVL CTRGTSPKTK PEKAISLEVQ ILAVDEKIKV KSTDVKTPTK
    61  FEMEDIAASA AAQTKLGAPL REKMGYRGTL RVALEILKER TNLGGGRKPH ELESTTPSQL
   121  SQKVPEKPAS SVPREDDWRC KGDLRRSLGK RENPSSPTVP SESKRALRDD RSQEPTAIAP
   181  TPGALPGDRS GAPRAIAPTP GAMLSGRSRA RRAIAPTPSA LRGYRSWAHR AIAPTPGCLY
   241  SDRSRAHRAI APARGTKHGG RSWACRSIAP KPGSLCGDRS QASRAIDPTL GARRGGRSRA
   301  HRAIAPTPGS LCGNRSRACG AIALTPGVLC GVRSRVPKDI TPTPGALRGY KSWVCRAIAP
   361  TPGALRGDRS AARTAVVRTP GALGRDRSRA RSAIASTPGT LQGNRSSVSK AIAPTPGALR
   421  GDRSAARTAF VPTPGALHRD RSRARSAIAS TPGTLRGNTS SACKAIAPTP GALRGYKSWA
   481  RRAIAPNPGA WRGYRSTTGT AIAPNLGALG GNRSAARTDI APTPGALRGY RSWTRRAIAP
   541  TPGTLSSYRS RSRRTIASTP ATLRGEKSRA HTSLAPTPGA LRGDGSRARR AIVPTTCPLC
   601  EIWSRVGIGI APIADALRRD RSPVRRAIAP TPGTLSGYRS RARTAIAPTP GTLRGYRPRS
   661  RRAIASTPAT LRGEKSRAHT SLAPAPGALR GDGSRARRAI VPTTCPLCEI WSRVGIGIAP
   721  IADALRRDRP PVRRAIAPTP GALRCDRSRE LTAIDPTPGA LCSDRSGASR AIAPTPGTLC
   781  SERSRVRRAI APTPCALCGK GSQVGMGVAP TPGALRRDRS QAGRAIAPTP SALFRVGSRV
   841  GTGIALPAGA LHRDRSPVRR AVAPTPGTLH CDGSRKCTAT GSTPGALPGD RSGVSKATAP
   901  APGALCSERS RARRSIAPTP CLLCGDRSWV GMGIAPTPGA LLGGKSRKCR AIAITPGALR
   961  GGRSQKRRVV APTPEALHGD GSWTYMAIAP TPGALHGDSS PAHTSIIPSP GALHGDGPPA
  1021  HMAFPSTPGT LHGDASHAHM AIAPTPGTMR GDSSTARTAT APSPGALRGD RSWKRKAIAS
  1081  TPGALHGNRS DRSRKCKAIA STPGTLHVER SPALRAIVPT PGTLGRDSSP GRTSIIPSPG
  1141  ALHGDRSPAH LDIASTPGAL HGDSSQAHTA IAPTPGTMRG DSSTARMAIA PSAGALRGDR
  1201  SWKRKAIAST PGALRGNRSD RSRKRKAIAS TPGALLGNRS DRSRKHKAIA PTPGAPRIDR
  1261  SPACRAIAPT PGALGDDSST AIAPTPGTPR GDSSPANTAI ASTPGALHGD TSQTHKAIAP
  1321  TPGDLGGGSS SAHKAITPSP GALHGDRSPA HTAIASTPGA LHGDSSQVHT TIAPTPGALR
  1381  DDKSWKRKAI APTPGTLHCD SSRTCTAFAP TPGALHADRS PAHQDITLTS GALHCDSSRE
  1441  SRAVAPILGA LHRVGSQAHK AIASTPGPLR GDSSPFHTAI APMPGALHGT RSWKREAISQ
  1501  TPFVTLCGDS SGERMAIAPT PGALHSDRSQ THTAIDPTPS VLRSDSSPAC MAIDPTPGAL
  1561  GRDRSQALMA IAPTPVGMQA HVLQSPRACQ DSLTLSRHVC EKKGKKRANA STLMSLPPTV
  1621  TEEGASLPPG LTSPAPPALK EETQDSRPKK ALAASPESSP FSGNIQDPGE GAWKPGWAGM
  1681  AASSGSRQHR LPSSLRLANR KRKRPGPDFQ RRPQGPQTPG DAKLANPVTT IQRAGGKQDG
  1741  QPPSLAFPQE PHPIERGTMV WFKFQDHPFW PAVVKSVSNT DKTARVLLLE ANLHHGKRGI
  1801  QVPLRRLKHL DCKEKEKLLK RAQKAYKQSV NWCFSLISHY REGLVRGSFR GSFLDYYAAD
  1861  ISYPIRRAIQ EGDLQIDFPK VNYGDLEDWE EETSLGGKRP CKKILPDRMR ASWDRDNQKL
  1921  VDFIVRRKGA DPHLLDILQG RKQSRWLTAF LKPHRDLHCI ETYLEDDDQL EVVAKHLQEI
  1981  YKQIDKARLT LIRDDKVNFV LEVLLPEAMI CTIAALDGLD YKAAEEKYLR GPPVHYREKE
  2041  LFDRNILKKA RREPATTHTA N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PWWP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 0.5 nTPM
  • cerebral cortex: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • testis: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • epididymal efferent duct ciliated cells: 0.4 nCPM
  • early primary spermatocytes: 0.1 nCPM
  • late primary spermatocytes: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 3.5 nTPM
  • basal ganglia: 3.3 nTPM
  • cerebral cortex: 1.4 nTPM
  • amygdala: 1.2 nTPM
  • midbrain: 1 nTPM
  • medulla oblongata: 0.9 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PWWP4 as an antibody target. Whether an autoantibody or antibody against PWWP4 could matter depends on whether native PWWP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PWWP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PWWP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PWWP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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