Seroatlas · Human Serome Atlas

PWWP3B

PWWP domain-containing DNA repair factor 3B

Also known as: FLJ33516, MUM1L1, PWP3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H9M0
Gene: PWWP3B
Ensembl: ENSG00000157502
Chromosome: X
Canonical length: 696 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein which contains a mutated melanoma-associated antigen 1 domain. Proteins which contain mutated antigens are expressed at high levels on certain types of cancers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

696 residues, UniProt reviewed canonical sequence.

>Q5H9M0|PWWP3B
     1  MESEYVLCNW KDQLWPAKVL SRSETSSNSK RKKAFSLEVQ ILSLDEKIKL DSTETKILNK
    61  SQIEAIAASL GLQSEDSAPP TEETAYGRSL KVALGILNER TNLSQASTSD EEEITMLSQN
   121  VPQKQSDSPP HKKYRKDEGD LPGCLEEREN SACLLASSES DDSLYDDKSQ APTMVDTIPS
   181  EVETKSLQNS SWCETFPSLS EDNDEKENKN KIDISAVMSV HSAVKEESAC VKDEKFAPPL
   241  SPLSSDMLIM PKALKEESED TCLETLAVPS ECSAFSENIE DPGEGPSNPC LDTSQNQPSM
   301  ESEMGAAACP GSCSRECEVS FSASNPVWDY SHLMSSERNF QRLDFEELEE EGQASDKSLL
   361  PSRINLSLLD DDEEDEELPR FILHYETHPF ETGMIVWFKY QKYPFWPAVI KSIRRKERKA
   421  SVLFVEANMN SEKKGIRVNF RRLKKFDCKE KQMLVDKARE DYSESIDWCI SLICDYRVRI
   481  GCGSFTGSLL EYYAADISYP VRKETKQDTF RNKFPKLHNE DAREPMAVTS QTKKMSFQKI
   541  LPDRMKAARD RANKNLVDFI VNAKGTENHL LAIVNGTKGS RWLKSFLNAN RFTPCIETYF
   601  EDEDQLDEVV KYLQEVCNQI DQIMPTWIKD DKIKFILEVL LPEAIICSIS AVDGLDYEAA
   661  EAKYLKGPCL GYRERELFDA KIIYEKRRKA PTNEAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PWWP3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

ovary: 104 nTPM
pancreas: 27 nTPM
testis: 17 nTPM
endometrium: 15 nTPM
cervix: 14 nTPM
skeletal muscle: 10 nTPM

Single-cell type

ovarian stromal cells: 292 nCPM
sertoli cells: 265 nCPM
peritubular myoid cells: 128 nCPM
leydig cells: 113 nCPM
gonadotrophs: 78 nCPM
epicardial cells: 73 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 27 nTPM
midbrain: 18 nTPM
pons: 12 nTPM
cerebral cortex: 10 nTPM
amygdala: 9.5 nTPM
basal ganglia: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.48
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular exosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PWWP3B as an antibody target. Whether an autoantibody or antibody against PWWP3B could matter depends on whether native PWWP3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PWWP3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PWWP3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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