Seroatlas · Human Serome Atlas

PWWP3A

PWWP domain-containing DNA repair factor 3A

Also known as: EXPAND1, MUM-1, MUM1, PWP3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TAK8
Gene: PWWP3A
Ensembl: ENSG00000160953
Chromosome: 19
Canonical length: 710 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables nucleosome binding activity. Involved in DNA repair and chromatin organization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

710 residues, UniProt reviewed canonical sequence.

>Q2TAK8|PWWP3A
     1  MADAKYVLCR WEKRLWPAKV LARTATSTKN KRRKEYFLAV QILSLEEKIK VKSTEVEILE
    61  KSQIEAIASS LASQNEVPAA PLEELAYRRS LRVALDVLSE GSIWSQESSA GTGRADRSLR
   121  GKPMEHVSSP CDSNSSSLPR GDVLGSSRPH RRRPCVQQSL SSSFTCEKDP ECKVDHKKGL
   181  RKSENPRGPL VLPAGGGAQD ESGSRIHHKN WTLASKRGGN SAQKASLCLN GSSLSEDDTE
   241  RDMGSKGGSW AAPSLPSGVR EDDPCANAEG HDPGLPLGSL TAPPAPEPSA CSEPGECPAK
   301  KRPRLDGSQR PPAVQLEPMA AGAAPSPGPG PGPRESVTPR STARLGPPPS HASADATRCL
   361  PCPDSQKLEK ECQSSEESMG SNSMRSILEE DEEDEEPPRV LLYHEPRSFE VGMLVWHKHK
   421  KYPFWPAVVK SVRQRDKKAS VLYIEGHMNP KMKGFTVSLK SLKHFDCKEK QTLLNQARED
   481  FNQDIGWCVS LITDYRVRLG CGSFAGSFLE YYAADISYPV RKSIQQDVLG TKLPQLSKGS
   541  PEEPVVGCPL GQRQPCRKML PDRSRAARDR ANQKLVEYIV KAKGAESHLR AILKSRKPSR
   601  WLQTFLSSSQ YVTCVETYLE DEGQLDLVVK YLQGVYQEVG AKVLQRTNGD RIRFILDVLL
   661  PEAIICAISA VDEVDYKTAE EKYIKGPSLS YREKEIFDNQ LLEERNRRRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PWWP3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 38 nTPM
cerebellum: 34 nTPM
testis: 31 nTPM
basal ganglia: 30 nTPM
amygdala: 30 nTPM
pituitary gland: 27 nTPM

Single-cell type

late primary spermatocytes: 229 nCPM
late spermatids: 195 nCPM
early primary spermatocytes: 176 nCPM
bergmann glia: 167 nCPM
retinal amacrine cells: 163 nCPM
thyrotrophs: 157 nCPM

Immune cell

basophil: 9.7 nTPM
eosinophil: 4.8 nTPM
NK-cell: 3.1 nTPM
gdT-cell: 2.9 nTPM
memory B-cell: 2.8 nTPM
plasmacytoid DC: 2.6 nTPM

Brain region

medulla oblongata: 63 nTPM
thalamus: 62 nTPM
midbrain: 59 nTPM
hypothalamus: 55 nTPM
pons: 55 nTPM
amygdala: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

nucleosome binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PWWP3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TP53BP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PWWP3A as an antibody target. Whether an autoantibody or antibody against PWWP3A could matter depends on whether native PWWP3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PWWP3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PWWP3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...