Seroatlas · Human Serome Atlas

PVALEF

Parvalbumin-like EF-hand-containing protein

Also known as: AATK-AS1, PVLEF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GWK0
Gene
PVALEF
Ensembl
ENSG00000225180
Chromosome
17
Canonical length
134 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in skeletal muscle contraction. Predicted to be part of troponin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>A0A1B0GWK0|PVALEF
     1  MEEDFSSQMK KMALAMGTSL SDKDIELLPT DMRHHGSFNY LKFFKHIRKL HASGQLDDAI
    61  HTAFQSLDKD KSGFIEWNEI KYILSIIPSS GPTTPLTDEE AEAMIQAADT HGDGRINYEE
   121  FSELIKKEKI PKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PVALEF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 0.2 nTPM
  • adipose tissue: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • somatotrophs: 18 nCPM
  • lactotrophs: 16 nCPM
  • retinal bipolar cells: 10 nCPM
  • gonadotrophs: 9.5 nCPM
  • oligodendrocytes: 8 nCPM
  • brain excitatory neurons: 7.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 2.4 nTPM
  • cerebellum: 1.8 nTPM
  • cerebral cortex: 1.7 nTPM
  • medulla oblongata: 1.5 nTPM
  • hypothalamus: 1.4 nTPM
  • basal ganglia: 1.1 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PVALEF as an antibody target. Whether an autoantibody or antibody against PVALEF could matter depends on whether native PVALEF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PVALEF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PVALEF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PVALEF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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