Seroatlas · Human Serome Atlas

PUS7L

Pseudouridylate synthase PUS7L

Also known as: DKFZP434G1415, PUS7L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0K6
Gene: PUS7L
Ensembl: ENSG00000129317
Chromosome: 12
Canonical length: 701 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Nuclear speckles

OverviewNCBI Gene

Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

701 residues, UniProt reviewed canonical sequence.

>Q9H0K6|PUS7L
     1  MEEDTDYRIR FSSLCFFNDH VGFHGTIKSS PSDFIVIEID EQGQLVNKTI DEPIFKISEI
    61  QLEPNNFPKK PKLDLQNLSL EDGRNQEVHT LIKYTDGDQN HQSGSEKEDT IVDGTSKCEE
   121  KADVLSSFLD EKTHELLNNF ACDVREKWLS KTELIGLPPE FSIGRILDKN QRASLHSAIR
   181  QKFPFLVTVG KNSEIVVKPN LEYKELCHLV SEEEAFDFFK YLDAKKENSK FTFKPDTNKD
   241  HRKAVHHFVN KKFGNLVETK SFSKMNCSAG NPNVVVTVRF REKAHKRGKR PLSECQEGKV
   301  IYTAFTLRKE NLEMFEAIGF LAIKLGVIPS DFSYAGLKDK KAITYQAMVV RKVTPERLKN
   361  IEKEIEKKRM NVFNIRSVDD SLRLGQLKGN HFDIVIRNLK KQINDSANLR ERIMEAIENV
   421  KKKGFVNYYG PQRFGKGRKV HTDQIGLALL KNEMMKAIKL FLTPEDLDDP VNRAKKYFLQ
   481  TEDAKGTLSL MPEFKVRERA LLEALHRFGM TEEGCIQAWF SLPHSMRIFY VHAYTSKIWN
   541  EAVSYRLETY GARVVQGDLV CLDEDIDDEN FPNSKIHLVT EEEGSANMYA IHQVVLPVLG
   601  YNIQYPKNKV GQWYHDILSR DGLQTCRFKV PTLKLNIPGC YRQILKHPCN LSYQLMEDHD
   661  IDVKTKGSHI DETALSLLIS FDLDASCYAT VCLKEIMKHD V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PUS7L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

retina: 11 nTPM
tonsil: 5.6 nTPM
thyroid gland: 5.5 nTPM
lymph node: 5.3 nTPM
cerebellum: 5.2 nTPM
breast: 5.1 nTPM

Single-cell type

brain inhibitory neurons: 123 nCPM
lactotrophs: 102 nCPM
other brain neurons: 100 nCPM
brain excitatory neurons: 96 nCPM
thyrotrophs: 92 nCPM
somatotrophs: 87 nCPM

Immune cell

basophil: 6.3 nTPM
naive CD8 T-cell: 2.9 nTPM
naive B-cell: 2.8 nTPM
MAIT T-cell: 2.7 nTPM
NK-cell: 2.5 nTPM
memory CD4 T-cell: 2.3 nTPM

Brain region

cerebellum: 27 nTPM
cerebral cortex: 24 nTPM
basal ganglia: 21 nTPM
white matter: 20 nTPM
hypothalamus: 20 nTPM
pons: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Pseudouridine synthase, TruD
Pseudouridine synthase, TruD, insertion domain
Pseudouridine synthase, catalytic domain superfamily
Pseudouridine synthase, TruD, catalytic domain
tRNA pseudouridine synthase D (TruD)
Pseudouridylate synthase PUS7L, R3H domain
Pseudouridylate synthase PUS7L, N-terminal domain
PUS7L N-terminal domain
PUS7L R3H domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PUS7L as an antibody target. Whether an autoantibody or antibody against PUS7L could matter depends on whether native PUS7L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PUS7L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PUS7L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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