PUDP

Protein identityUniProt · HPA

UniProt accession

Q08623

Gene

PUDP

Ensembl

ENSG00000130021

Chromosome

X

Canonical length

228 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The encoded protein has no known biological function. This gene has a pseudogene on chromosome 1. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q08623|PUDP
     1  MAAPPQPVTH LIFDMDGLLL DTERLYSVVF QEICNRYDKK YSWDVKSLVM GKKALEAAQI
    61  IIDVLQLPMS KEELVEESQT KLKEVFPTAA LMPGAEKLII HLRKHGIPFA LATSSGSASF
   121  DMKTSRHKEF FSLFSHIVLG DDPEVQHGKP DPDIFLACAK RFSPPPAMEK CLVFEDAPNG
   181  VEAALAAGMQ VVMVPDGNLS RDLTTKATLV LNSLQDFQPE LFGLPSYE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PUDP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

31 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PUDP.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 76 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.14

gnomAD pLI

0.13

DepMap mean gene effect

0.21

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• nucleotide metabolic process

Molecular functions

• metal ion binding
• phosphatase activity
• pseudouridine 5'-phosphatase activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• HAD hydrolase, subfamily IA
• Phosphoglycolate phosphatase-like, domain 2
• HAD superfamily
• HAD-like superfamily
• Haloacid dehalogenase-like hydrolase
• Phosphatase Gpp1/Gpp2-like
• Haloacid dehalogenase-like hydrolase

KeywordsUniProt

• Hydrolase
• Magnesium
• Metal-binding
• Nucleotide metabolism