Seroatlas · Human Serome Atlas

PTX4

Pentraxin-4

Also known as: C16orf38, PTX4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A99
Gene: PTX4
Ensembl: ENSG00000251692
Chromosome: 16
Canonical length: 478 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

This gene belongs to the pentraxin superfamily, whose members encode highly conserved multifunctional proteins. The encoded protein, like other members of this family, contains a conserved pentraxin domain at the C-terminus. The highest levels of expression of the protein were observed in bone marrow, small intestine and testes. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>Q96A99|PTX4
     1  MGCSWRKTLS FFLVFVPIYL HGASSQEAAP VGPRKPFFER LRRLEEQFRR FQEVTWTHLQ
    61  NIASNYNVSY NVDVRFRSLA EESQAVAQAV NRSQASVQGE LAQLKAWVRK LQRRGRKVDT
   121  RLRALDLTLG ERSQQRARER KAHKAQRDAL QDSLARLEGL VHSQGARLAA LEGRLPVAHP
   181  GTAALGPALV PTPTQPEELG PTSLKLQRDR QELRAASEHR GPPQDSSAPL QGRREPPASG
   241  SHRVLSGTAP KDPRQQAWSP QVPGEICGVG PTLVFPNAST RNVVFLSPGF VTALRALSFC
   301  SWVRTASGRL GTLLSYATED NDNKLVLHGR DSLLPGSIHF VIGDPAFREL PLQLLLDGQW
   361  HHICVIWTST QGRYWLHVDR RLVATGSRFR EGYEIPPGGS LVLGQEQDSV GGGFDSSEAF
   421  VGSMSGLAIW DRALVPGEVA NLAIGKEFPT GAILTLANAA LAGGFVQGAN CTCLERCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.7 nTPM
testis: 0.5 nTPM
adrenal gland: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM

Single-cell type

late spermatids: 0.4 nCPM
neutrophil progenitors: 0.3 nCPM
ependymal cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

non-classical monocyte: 0.6 nTPM
intermediate monocyte: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

midbrain: 6.4 nTPM
medulla oblongata: 4.2 nTPM
pons: 2.7 nTPM
hypothalamus: 1.9 nTPM
amygdala: 1.3 nTPM
hippocampal formation: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: -0.61
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

metal ion binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTX4 as an antibody target. Whether an autoantibody or antibody against PTX4 could matter depends on whether native PTX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTX4 is annotated as secreted, so native PTX4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PTX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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