Seroatlas · Human Serome Atlas

PTTG3P

Putative pituitary tumor-transforming gene 3 protein

Also known as: PTTG3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZH4
Gene: PTTG3P
Canonical length: 202 aa

OverviewNCBI Gene

No narrative summary is available for PTTG3P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>Q9NZH4|PTTG3P
     1  MATLIYVDKE NEEPGILVAT KDGLKLGSGP SIKALDGRSQ VSISCFGKTF DAPTSLPKAT
    61  RKALGTVNRA TEKSVKTNGP LKQKQPSFSA KKMTEKTVKA KNSVPASDDG YPEIEKLFPF
   121  NPLGFESFDL PEEHQIAHLP LSEVPLMILD EERELEKLFQ LGPPSPLKMP SPPWKSNLLQ
   181  SPLSILLTLD VELPPVCSDI DI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTTG3P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69

OntologyGO

Biological processes

Molecular functions

SH3 domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTTG3P as an antibody target. Whether an autoantibody or antibody against PTTG3P could matter depends on whether native PTTG3P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTTG3P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTTG3P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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