Seroatlas · Human Serome Atlas

PTTG1IP2

PTTG1IP family member 2

Also known as: PTIP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DTF9
Gene
PTTG1IP2
Ensembl
ENSG00000251154
Chromosome
7
Canonical length
154 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>P0DTF9|PTTG1IP2
     1  MCWLRAWGQI LLPVFLSLFL IQLLISFSEN GFIHSPRNNQ KPRDGNEEEC AVKKSCQLCT
    61  EDKKCVWCSE EKACKKYCFP YFGCRFSSIY WLNCKVDMFG IMMLLLIAVL ITGFVWYCCA
   121  YHFYLQDLNR NRVYFYGRRE TVPIHDRSAT VYDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTTG1IP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 52 nCPM
  • late primary spermatocytes: 50 nCPM
  • late spermatids: 2.6 nCPM
  • leydig cells: 0.4 nCPM
  • pancreatic acinar cells: 0.1 nCPM
  • adipocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.4 nTPM
  • hypothalamus: 0.3 nTPM
  • amygdala: 0.2 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebellum: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTTG1IP2 as an antibody target. Whether an autoantibody or antibody against PTTG1IP2 could matter depends on whether native PTTG1IP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTTG1IP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTTG1IP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTTG1IP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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