Seroatlas · Human Serome Atlas

PTRH1

Peptidyl-tRNA hydrolase

Also known as: C9orf115, PTH_HUMAN, PTH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86Y79
Gene: PTRH1
Ensembl: ENSG00000187024
Chromosome: 9
Canonical length: 214 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables peptidyl-tRNA hydrolase activity. Involved in rescue of stalled ribosome. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q86Y79|PTRH1
     1  MRPGGFLGAG QRLSRAMSRC VLEPRPPGKR WMVAGLGNPG LPGTRHSVGM AVLGQLARRL
    61  GVAESWTRDR HCAADLALAP LGDAQLVLLR PRRLMNANGR SVARAAELFG LTAEEVYLVH
   121  DELDKPLGRL ALKLGGSARG HNGVRSCISC LNSNAMPRLR VGIGRPAHPE AVQAHVLGCF
   181  SPAEQELLPL LLDRATDLIL DHIRERSQGP SLGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTRH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

skin: 22 nTPM
adrenal gland: 22 nTPM
kidney: 22 nTPM
pancreas: 18 nTPM
amygdala: 18 nTPM
thyroid gland: 18 nTPM

Single-cell type

early spermatids: 128 nCPM
epicardial cells: 114 nCPM
epididymal efferent duct absorptive cells: 106 nCPM
respiratory ciliated cells: 101 nCPM
peritubular myoid cells: 84 nCPM
decidual stromal cells: 76 nCPM

Immune cell

MAIT T-cell: 70 nTPM
memory CD8 T-cell: 69 nTPM
gdT-cell: 68 nTPM
naive CD8 T-cell: 57 nTPM
intermediate monocyte: 37 nTPM
T-reg: 37 nTPM

Brain region

cerebral cortex: 24 nTPM
hippocampal formation: 21 nTPM
amygdala: 21 nTPM
thalamus: 20 nTPM
white matter: 20 nTPM
basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

rescue of stalled ribosome

Molecular functions

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Peptidyl-tRNA hydrolase
Peptidyl-tRNA hydrolase, conserved site
Peptidyl-tRNA hydrolase superfamily
Peptidyl-tRNA hydrolase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTRH1 as an antibody target. Whether an autoantibody or antibody against PTRH1 could matter depends on whether native PTRH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTRH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTRH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...