Seroatlas · Human Serome Atlas

PTPRCAP

Protein tyrosine phosphatase receptor type C-associated protein

Also known as: CD45-AP, LPAP, PTCA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14761
Gene: PTPRCAP
Ensembl: ENSG00000213402
Chromosome: 11
Canonical length: 206 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q14761|PTPRCAP
     1  MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL ALAWRRLSRD
    61  SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST DNDLERQEDE QDTDYDHVAD
   121  GGLQADPGEG EQQCGEASSP EQVPVRAEEA RDSDTEGDLV LGSPGPASAG GSAEALLSDL
   181  HAFAGSAAWD DSARAAGGQG LHVTAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPRCAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 254 nTPM

Expression across tissuesHPA

Tissue

spleen: 254 nTPM
lymph node: 118 nTPM
small intestine: 113 nTPM
thymus: 102 nTPM
appendix: 69 nTPM
tonsil: 48 nTPM

Single-cell type

nk-cells: 12 nCPM
b-cells: 8.4 nCPM
microglia: 7.4 nCPM
t-cells: 6.6 nCPM
astrocytes: 5.3 nCPM
bergmann glia: 5 nCPM

Immune cell

naive B-cell: 1,721 nTPM
gdT-cell: 1,564 nTPM
memory CD8 T-cell: 1,381 nTPM
T-reg: 1,378 nTPM
memory B-cell: 1,339 nTPM
MAIT T-cell: 1,325 nTPM

Brain region

medulla oblongata: 4.2 nTPM
white matter: 3.4 nTPM
spinal cord: 3.3 nTPM
pons: 2.8 nTPM
choroid plexus: 2.7 nTPM
cerebral cortex: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0.54
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

defense response

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

Protein tyrosine phosphatase receptor type C-associated protein
Protein tyrosine phosphatase receptor type C-associated

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTPRCAP as an antibody target. Whether an autoantibody or antibody against PTPRCAP could matter depends on whether native PTPRCAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTPRCAP is annotated at the cell surface, where native PTPRCAP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTPRCAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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