PTPN9

Protein identityUniProt · HPA

UniProt accession

P43378

Gene

PTPN9

Ensembl

ENSG00000169410

Chromosome

15

Canonical length

593 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>P43378|PTPN9
     1  MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF LMARKFDVLR
    61  AIELFHSYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN VRDPTGASIA LFTARLHHPH
   121  KSVQHVVLQA LFYLLDRAVD SFETQRNGLV FIYDMCGSNY ANFELDLGKK VLNLLKGAFP
   181  ARLKKVLIVG APIWFRVPYS IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK
   241  IDLATWNFQF LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNARQK
   301  QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS GHTQTDYINA
   361  SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM TTRFEEGGRR KCGQYWPLEK
   421  DSRIRFGFLT VTNLGVENMN HYKKTTLEIH NTEERQKRQV THFQFLSWPD YGVPSSAASL
   481  IDFLRVVRNQ QSLAVSNMGA RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT
   541  LNVFQTVSRM RTQRAFSIQT PEQYYFCYKA ILEFAEKEGM VSSGQNLLAV ESQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPN9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

15 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.46

gnomAD pLI

0.11

gnomAD missense Z

2.1

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of neuron projection development
• peptidyl-tyrosine dephosphorylation
• positive regulation of protein localization to plasma membrane
• protein dephosphorylation
• signal transduction

Molecular functions

• non-membrane spanning protein tyrosine phosphatase activity
• protein tyrosine phosphatase activity

Cellular components

• cytoplasm
• neuron projection terminus
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Tyrosine-specific protein phosphatase, PTPase domain
• Tyrosine-specific protein phosphatases domain
• CRAL-TRIO lipid binding domain
• Protein-tyrosine phosphatase, catalytic
• CRAL/TRIO, N-terminal domain
• Protein-tyrosine phosphatase, active site
• Protein-tyrosine phosphatase-like
• CRAL/TRIO, N-terminal domain superfamily
• CRAL-TRIO lipid binding domain superfamily
• Protein-Tyrosine Phosphatase
• Protein-tyrosine phosphatase
• CRAL/TRIO domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Hydrolase
• Protein phosphatase

InteractionsUniProt · HPA

Protein binding partners of PTPN9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GHR