Seroatlas · Human Serome Atlas

PTPN20

Tyrosine-protein phosphatase non-receptor type 20

Also known as: bA142I17.1, bA42B19.1, CT126, DKFZP566K0524, PTN20_HUMAN, PTPN20A, PTPN20B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4JDL3
Gene: PTPN20
Ensembl: ENSG00000204179
Chromosome: 10
Canonical length: 420 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Centriolar satellite

OverviewNCBI Gene

The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q4JDL3|PTPN20
     1  MSSPRDFRAE PVNDYEGNDS EAEDLNFRET LPSSSQENTP RSKVFENKVN SEKVKLSLRN
    61  FPHNDYEDVF EEPSESGSDP SMWTARGPFR RDRWSSEDEE AAGPSQALSP LLSDTRKIVS
   121  EGELDQLAQI RPLIFNFHEQ TAIKDCLKIL EEKTAAYDIM QEFMALELKN LPGEFNSGNQ
   181  PSNREKNRYR DILPYDSTRV PLGKSKDYIN ASYIRIVNCG EEYFYIATQG PLLSTIDDFW
   241  QMVLENNSNV IAMITREIEG GIIKCYHYWP ISLKKPLELK HFRVFLENYQ ILQYFIIRMF
   301  QVVEKSTGTS HSVKQLQFTK WPDHGTPASA DSFIKYIRYA RKSHLTGPMV VHCSAGIGRT
   361  GVFLCVDVVF CAIVKNCSFN IMDIVAQMRE QRSGMVQTKE QYHFCYDIVL EVLRKLLTLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPN20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

tongue: 14 nTPM
testis: 13 nTPM
skeletal muscle: 12 nTPM
adrenal gland: 8.6 nTPM
heart muscle: 8.5 nTPM
cerebellum: 7.3 nTPM

Single-cell type

proximal tubule cells: 83 nCPM
early spermatids: 72 nCPM
distal convoluted tubule cells: 62 nCPM
gonadotrophs: 55 nCPM
renal connecting tubule cells: 52 nCPM
cardiomyocytes: 49 nCPM

Immune cell

naive CD8 T-cell: 0.9 nTPM
memory B-cell: 0.8 nTPM
NK-cell: 0.8 nTPM
plasmacytoid DC: 0.7 nTPM
naive CD4 T-cell: 0.6 nTPM
memory CD4 T-cell: 0.5 nTPM

Brain region

pons: 44 nTPM
medulla oblongata: 25 nTPM
midbrain: 24 nTPM
choroid plexus: 24 nTPM
cerebellum: 23 nTPM
hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0.02
DepMap mean gene effect: -0.22
DepMap dependency class: selective

OntologyGO

Biological processes

lymphangiogenesis

Molecular functions

phosphoprotein phosphatase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTPN20 as an antibody target. Whether an autoantibody or antibody against PTPN20 could matter depends on whether native PTPN20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTPN20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTPN20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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