Seroatlas · Human Serome Atlas

PTP4A3

Protein tyrosine phosphatase type IVA 3

Also known as: PRL-3, PRL-R, PRL3, TP4A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75365
Gene: PTP4A3
Ensembl: ENSG00000184489
Chromosome: 8
Canonical length: 173 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>O75365|PTP4A3
     1  MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK
    61  DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI
   121  ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTP4A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 565 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 565 nTPM
heart muscle: 517 nTPM
pituitary gland: 163 nTPM
blood vessel: 133 nTPM
pancreas: 95 nTPM
stomach: 79 nTPM

Single-cell type

renal collecting duct intercalated cells: 19 nCPM
vascular smooth muscle cells: 19 nCPM
other brain neurons: 15 nCPM
cardiomyocytes: 13 nCPM
brain inhibitory neurons: 11 nCPM
podocytes: 11 nCPM

Immune cell

neutrophil: 55 nTPM
non-classical monocyte: 54 nTPM
intermediate monocyte: 28 nTPM
eosinophil: 13 nTPM
plasmacytoid DC: 8.6 nTPM
naive CD4 T-cell: 6.6 nTPM

Brain region

thalamus: 17 nTPM
cerebral cortex: 14 nTPM
amygdala: 13 nTPM
hypothalamus: 11 nTPM
pons: 11 nTPM
medulla oblongata: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTP4A3.

Disease | ImmuneIEDB

Conditions an epitope on PTP4A3 was assayed in.

colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0.05
gnomAD missense Z: 1.06
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein tyrosine phosphatase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTP4A3 as an antibody target. Whether an autoantibody or antibody against PTP4A3 could matter depends on whether native PTP4A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTP4A3 is annotated at the cell surface, where native PTP4A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTP4A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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