Seroatlas · Human Serome Atlas

PTMS

Parathymosin

Also known as: ParaT, PTMS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20962
Gene
PTMS
Ensembl
ENSG00000159335
Chromosome
12
Canonical length
102 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Predicted to enable histone binding activity. Predicted to be involved in negative regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

102 residues, UniProt reviewed canonical sequence.

>P20962|PTMS
     1  MSEKSVEAAA ELSAKDLKEK KEKVEEKASR KERKKEVVEE EENGAEEEEE ETAEDGEEED
    61  EGEEEDEEEE EEDDEGPALK RAAEEEDEAD PKRQKTENGA SA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTMS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
760 nTPM

Expression across tissuesHPA

Tissue

  • liver: 760 nTPM
  • endometrium: 425 nTPM
  • colon: 394 nTPM
  • blood vessel: 369 nTPM
  • cerebellum: 334 nTPM
  • ovary: 318 nTPM

Single-cell type

  • hofbauer cells: 876 nCPM
  • hepatocytes: 743 nCPM
  • smooth muscle cells: 620 nCPM
  • peritubular myoid cells: 616 nCPM
  • megakaryocytes: 606 nCPM
  • breast myoepithelial cells: 499 nCPM

Immune cell

  • basophil: 26 nTPM
  • plasmacytoid DC: 4.4 nTPM
  • eosinophil: 3.6 nTPM
  • gdT-cell: 1.3 nTPM
  • neutrophil: 1.3 nTPM
  • memory CD8 T-cell: 1.1 nTPM

Brain region

  • hippocampal formation: 307 nTPM
  • amygdala: 300 nTPM
  • cerebral cortex: 286 nTPM
  • basal ganglia: 279 nTPM
  • cerebellum: 273 nTPM
  • hypothalamus: 240 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0.2
gnomAD missense Z
0.81
DepMap mean gene effect
-0.35
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTMS as an antibody target. Whether an autoantibody or antibody against PTMS could matter depends on whether native PTMS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTMS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTMS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTMS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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