PTH2
Tuberoinfundibular peptide of 39 residues
Also known as: TIP39, TIP39_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96A98
- Gene
- PTH2
- Ensembl
- ENSG00000142538
- Chromosome
- 19
- Canonical length
- 100 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in brain
OverviewNCBI Gene
This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. [provided by RefSeq, Jul 2015]
Canonical amino-acid sequenceUniProt
100 residues, UniProt reviewed canonical sequence.
>Q96A98|PTH2
1 METRQVSRSP RVRLLLLLLL LLVVPWGVRT ASGVALPPVG VLSLRPPGRA WADPATPRPR
61 RSLALADDAA FRERARLLAA LERRHWLNSY MHKLLVLDAPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PTH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 1 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 1 nTPM
- midbrain: 0.2 nTPM
- testis: 0.2 nTPM
- cerebral cortex: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
Single-cell type
- innate lymphoid cells: 14 nCPM
- oocytes: 9.2 nCPM
- megakaryocytes: 6.2 nCPM
- late spermatids: 4 nCPM
- late primary spermatocytes: 3.5 nCPM
- brain excitatory neurons: 2.1 nCPM
Immune cell
- naive B-cell: 0.7 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- midbrain: 7.8 nTPM
- cerebellum: 4.4 nTPM
- thalamus: 2.9 nTPM
- pons: 1.8 nTPM
- cerebral cortex: 1.7 nTPM
- hippocampal formation: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.44
- DepMap mean gene effect
- -0.15
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Tuberoinfundibular peptide of 39 residues
- TIP39 peptide
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PTH2 as an antibody target. Whether an autoantibody or antibody against PTH2 could matter depends on whether native PTH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PTH2 is annotated as secreted, so native PTH2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PTH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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