Seroatlas · Human Serome Atlas

PTGS1

Prostaglandin G/H synthase 1

Also known as: COX1, PGH1_HUMAN, PGHS-1, PTGHS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23219
Gene
PTGS1
Ensembl
ENSG00000095303
Chromosome
9
Canonical length
599 aa
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This is one of two genes encoding similar enzymes that catalyze the conversion of arachidonate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2021]

Canonical amino-acid sequenceUniProt

599 residues, UniProt reviewed canonical sequence.

>P23219|PTGS1
     1  MSRSLLLWFL LFLLLLPPLP VLLADPGAPT PVNPCCYYPC QHQGICVRFG LDRYQCDCTR
    61  TGYSGPNCTI PGLWTWLRNS LRPSPSFTHF LLTHGRWFWE FVNATFIREM LMRLVLTVRS
   121  NLIPSPPTYN SAHDYISWES FSNVSYYTRI LPSVPKDCPT PMGTKGKKQL PDAQLLARRF
   181  LLRRKFIPDP QGTNLMFAFF AQHFTHQFFK TSGKMGPGFT KALGHGVDLG HIYGDNLERQ
   241  YQLRLFKDGK LKYQVLDGEM YPPSVEEAPV LMHYPRGIPP QSQMAVGQEV FGLLPGLMLY
   301  ATLWLREHNR VCDLLKAEHP TWGDEQLFQT TRLILIGETI KIVIEEYVQQ LSGYFLQLKF
   361  DPELLFGVQF QYRNRIAMEF NHLYHWHPLM PDSFKVGSQE YSYEQFLFNT SMLVDYGVEA
   421  LVDAFSRQIA GRIGGGRNMD HHILHVAVDV IRESREMRLQ PFNEYRKRFG MKPYTSFQEL
   481  VGEKEMAAEL EELYGDIDAL EFYPGLLLEK CHPNSIFGES MIEIGAPFSL KGLLGNPICS
   541  PEYWKPSTFG GEVGFNIVKT ATLKKLVCLN TKTCPYVSFR VPDASQDDGP AVERPSTEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
228 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 228 nTPM
  • skin: 144 nTPM
  • colon: 102 nTPM
  • esophagus: 63 nTPM
  • fallopian tube: 41 nTPM
  • rectum: 23 nTPM

Single-cell type

  • platelets: 1,502 nCPM
  • tuft cells: 795 nCPM
  • endometrial luminal cells: 498 nCPM
  • megakaryocytes: 284 nCPM
  • mast cells: 220 nCPM
  • smooth muscle cells: 174 nCPM

Immune cell

  • basophil: 29 nTPM
  • eosinophil: 23 nTPM
  • total PBMC: 22 nTPM
  • myeloid DC: 20 nTPM
  • intermediate monocyte: 13 nTPM
  • classical monocyte: 12 nTPM

Brain region

  • white matter: 26 nTPM
  • hippocampal formation: 16 nTPM
  • thalamus: 15 nTPM
  • spinal cord: 15 nTPM
  • cerebral cortex: 14 nTPM
  • medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
0.57
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGS1 as an antibody target. Whether an autoantibody or antibody against PTGS1 could matter depends on whether native PTGS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTGS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTGS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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