Seroatlas · Human Serome Atlas

PTGIR

Prostacyclin receptor

Also known as: IP, PI2R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P43119
Gene: PTGIR
Ensembl: ENSG00000160013
Chromosome: 19
Canonical length: 386 aa
Protein class: FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>P43119|PTGIR
     1  MADSCRNLTY VRGSVGPATS TLMFVAGVVG NGLALGILSA RRPARPSAFA VLVTGLAATD
    61  LLGTSFLSPA VFVAYARNSS LLGLARGGPA LCDAFAFAMT FFGLASMLIL FAMAVERCLA
   121  LSHPYLYAQL DGPRCARLAL PAIYAFCVLF CALPLLGLGQ HQQYCPGSWC FLRMRWAQPG
   181  GAAFSLAYAG LVALLVAAIF LCNGSVTLSL CRMYRQQKRH QGSLGPRPRT GEDEVDHLIL
   241  LALMTVVMAV CSLPLTIRCF TQAVAPDSSS EMGDLLAFRF YAFNPILDPW VFILFRKAVF
   301  QRLKLWVCCL CLGPAHGDSQ TPLSQLASGR RDPRAPSAPV GKEGSCVPLS AWGEGQVEPL
   361  PPTQQSSGSA VGTSSKAEAS VACSLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGIR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 73 nTPM
lung: 55 nTPM
heart muscle: 27 nTPM
thyroid gland: 17 nTPM
kidney: 16 nTPM
adipose tissue: 13 nTPM

Single-cell type

platelets: 312 nCPM
cdc: 75 nCPM
vascular smooth muscle cells: 63 nCPM
hepatic stellate cells: 45 nCPM
pericytes: 41 nCPM
megakaryocytes: 31 nCPM

Immune cell

intermediate monocyte: 65 nTPM
non-classical monocyte: 39 nTPM
classical monocyte: 28 nTPM
myeloid DC: 21 nTPM
total PBMC: 18 nTPM
T-reg: 3.9 nTPM

Brain region

cerebral cortex: 1.3 nTPM
medulla oblongata: 0.9 nTPM
spinal cord: 0.9 nTPM
hippocampal formation: 0.8 nTPM
midbrain: 0.6 nTPM
pons: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

guanyl-nucleotide exchange factor activity
prostacyclin receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
Prostanoid receptor
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Prostacyclin (prostanoid IP) receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGIR as an antibody target. Whether an autoantibody or antibody against PTGIR could matter depends on whether native PTGIR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGIR is annotated at the cell surface, where native PTGIR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTGIR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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