Seroatlas · Human Serome Atlas

PTGFR

Prostaglandin F2-alpha receptor

Also known as: FP, PF2R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43088
Gene
PTGFR
Ensembl
ENSG00000122420
Chromosome
1
Canonical length
359 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>P43088|PTGFR
     1  MSMNNSKQLV SPAAALLSNT TCQTENRLSV FFSVIFMTVG ILSNSLAIAI LMKAYQRFRQ
    61  KSKASFLLLA SGLVITDFFG HLINGAIAVF VYASDKEWIR FDQSNVLCSI FGICMVFSGL
   121  CPLLLGSVMA IERCIGVTKP IFHSTKITSK HVKMMLSGVC LFAVFIALLP ILGHRDYKIQ
   181  ASRTWCFYNT EDIKDWEDRF YLLLFSFLGL LALGVSLLCN AITGITLLRV KFKSQQHRQG
   241  RSHHLEMVIQ LLAIMCVSCI CWSPFLVTMA NIGINGNHSL ETCETTLFAL RMATWNQILD
   301  PWVYILLRKA VLKNLYKLAS QCCGVHVISL HIWELSSIKN SLKVAAISES PVAEKSAST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGFR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 19 nTPM
  • endometrium: 17 nTPM
  • smooth muscle: 16 nTPM
  • urinary bladder: 11 nTPM
  • adipose tissue: 8.7 nTPM
  • placenta: 7.6 nTPM

Single-cell type

  • alveolar cells type 2: 158 nCPM
  • fibro-adipogenic progenitors: 143 nCPM
  • loop of henle epithelial cells: 79 nCPM
  • fibroblasts: 73 nCPM
  • renal connecting tubule cells: 67 nCPM
  • respiratory secretory cells: 64 nCPM

Immune cell

  • classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 7.1 nTPM
  • hippocampal formation: 3.8 nTPM
  • pons: 3.7 nTPM
  • cerebral cortex: 3.6 nTPM
  • medulla oblongata: 1.4 nTPM
  • amygdala: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0.07
gnomAD missense Z
1.17
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGFR as an antibody target. Whether an autoantibody or antibody against PTGFR could matter depends on whether native PTGFR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGFR is annotated at the cell surface, where native PTGFR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTGFR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTGFR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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