Seroatlas · Human Serome Atlas

PTGER3

Prostaglandin E2 receptor EP3 subtype

Also known as: EP3, lnc003875, PE2R3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43115
Gene
PTGER3
Ensembl
ENSG00000050628
Chromosome
1
Canonical length
390 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>P43115|PTGER3
     1  MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV SVAFPITMLL
    61  TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL VGQLLTTPVV IVVYLSKQRW
   121  EHIDPSGRLC TFFGLTMTVF GLSSLFIASA MAVERALAIR APHWYASHMK TRATRAVLLG
   181  VWLAVLAFAL LPVLGVGQYT VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL
   241  ALTVTFSCNL ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI
   301  MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR KILLRKFCQI
   361  RYHTNNYASS STSLPCQCSS TLMWSDHLER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGER3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
81 nTPM

Expression across tissuesHPA

Tissue

  • endometrium: 81 nTPM
  • kidney: 75 nTPM
  • smooth muscle: 63 nTPM
  • adipose tissue: 51 nTPM
  • breast: 28 nTPM
  • blood vessel: 25 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 1,517 nCPM
  • distal convoluted tubule cells: 1,009 nCPM
  • adipocytes: 734 nCPM
  • renal connecting tubule cells: 526 nCPM
  • loop of henle epithelial cells: 525 nCPM
  • epididymal clear cells: 292 nCPM

Immune cell

  • basophil: 40 nTPM
  • myeloid DC: 0.6 nTPM
  • MAIT T-cell: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • choroid plexus: 23 nTPM
  • hypothalamus: 20 nTPM
  • cerebral cortex: 15 nTPM
  • amygdala: 13 nTPM
  • medulla oblongata: 11 nTPM
  • basal ganglia: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.37
gnomAD missense Z
1.31
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGER3 as an antibody target. Whether an autoantibody or antibody against PTGER3 could matter depends on whether native PTGER3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGER3 is annotated at the cell surface, where native PTGER3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTGER3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTGER3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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