Seroatlas · Human Serome Atlas

PTGER2

Prostaglandin E2 receptor EP2 subtype

Also known as: EP2, PE2R2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43116
Gene
PTGER2
Ensembl
ENSG00000125384
Chromosome
14
Canonical length
358 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>P43116|PTGER2
     1  MGNASNDSQS EDCETRQWLP PGESPAISSV MFSAGVLGNL IALALLARRW RGDVGCSAGR
    61  RSSLSLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLV ALAPESRACT YFAFAMTFFS
   121  LATMLMLFAM ALERYLSIGH PYFYQRRVSR SGGLAVLPVI YAVSLLFCSL PLLDYGQYVQ
   181  YCPGTWCFIR HGRTAYLQLY ATLLLLLIVS VLACNFSVIL NLIRMHRRSR RSRCGPSLGS
   241  GRGGPGARRR GERVSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMNETS SRKEKWDLQA
   301  LRFLSINSII DPWVFAILRP PVLRLMRSVL CCRISLRTQD ATQTSCSTQS DASKQADL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 36 nTPM
  • stomach: 17 nTPM
  • cervix: 16 nTPM
  • placenta: 14 nTPM
  • appendix: 12 nTPM
  • ovary: 11 nTPM

Single-cell type

  • monocytes: 98 nCPM
  • nk-cells: 69 nCPM
  • t-cells: 54 nCPM
  • kupffer cells: 49 nCPM
  • neutrophil progenitors: 49 nCPM
  • mucous neck cells: 44 nCPM

Immune cell

  • MAIT T-cell: 130 nTPM
  • memory CD8 T-cell: 114 nTPM
  • gdT-cell: 107 nTPM
  • memory CD4 T-cell: 91 nTPM
  • NK-cell: 74 nTPM
  • naive CD8 T-cell: 68 nTPM

Brain region

  • choroid plexus: 6.4 nTPM
  • medulla oblongata: 1.7 nTPM
  • basal ganglia: 1.5 nTPM
  • spinal cord: 1.4 nTPM
  • midbrain: 1.3 nTPM
  • cerebral cortex: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTGER2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 57 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0.01
gnomAD missense Z
0.39
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGER2 as an antibody target. Whether an autoantibody or antibody against PTGER2 could matter depends on whether native PTGER2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGER2 is annotated at the cell surface, where native PTGER2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTGER2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTGER2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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