Seroatlas · Human Serome Atlas

PTGER1

Prostaglandin E2 receptor EP1 subtype

Also known as: EP1, PE2R1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P34995
Gene
PTGER1
Ensembl
ENSG00000160951
Chromosome
19
Canonical length
402 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>P34995|PTGER1
     1  MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN LLALALLAQA
    61  AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT AGRAPAGGAC HFLGGCMVFF
   121  GLCPLLLGCG MAVERCVGVT RPLLHAARVS VARARLALAA VAAVALAVAL LPLARVGRYE
   181  LQYPGTWCFI GLGPPGGWRQ ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR
   241  PPPASGPDSR RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV
   301  GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV YILLRQAVLR
   361  QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS HF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 26 nTPM
  • spleen: 6.1 nTPM
  • stomach: 3 nTPM
  • lung: 2.4 nTPM
  • adrenal gland: 1.4 nTPM
  • pituitary gland: 1.4 nTPM

Single-cell type

  • renal collecting duct principal cells: 29 nCPM
  • pericytes: 15 nCPM
  • megakaryocytes: 12 nCPM
  • renal connecting tubule cells: 7.7 nCPM
  • oocytes: 4.6 nCPM
  • epicardial cells: 4.5 nCPM

Immune cell

  • NK-cell: 0.5 nTPM
  • intermediate monocyte: 0.3 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • myeloid DC: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • cerebral cortex: 5.5 nTPM
  • hypothalamus: 3.1 nTPM
  • choroid plexus: 2.9 nTPM
  • white matter: 2.6 nTPM
  • basal ganglia: 2.4 nTPM
  • pons: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0
gnomAD missense Z
0.75
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGER1 as an antibody target. Whether an autoantibody or antibody against PTGER1 could matter depends on whether native PTGER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGER1 is annotated at the cell surface, where native PTGER1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTGER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTGER1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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