Seroatlas · Human Serome Atlas

PTGDS

Prostaglandin-H2 D-isomerase

Also known as: L-PGDS, PGDS, PTGDS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41222
Gene
PTGDS
Ensembl
ENSG00000107317
Chromosome
9
Canonical length
190 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>P41222|PTGDS
     1  MATHHTLWMG LALLGVLGDL QAAPEAQVSV QPNFQQDKFL GRWFSAGLAS NSSWLREKKA
    61  ALSMCKSVVA PATDGGLNLT STFLRKNQCE TRTMLLQPAG SLGSYSYRSP HWGSTYSVSV
   121  VETDYDQYAL LYSQGSKGPG EDFRMATLYS RTQTPRAELK EKFTAFCKAQ GFTEDTIVFL
   181  PQTDKCMTEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGDS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
4,605 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 4,605 nTPM
  • spinal cord: 3,338 nTPM
  • midbrain: 3,250 nTPM
  • testis: 3,126 nTPM
  • basal ganglia: 2,972 nTPM
  • amygdala: 2,493 nTPM

Single-cell type

  • peritubular myoid cells: 43,552 nCPM
  • leydig cells: 23,234 nCPM
  • retinal pigment epithelial cells: 8,854 nCPM
  • epididymal principal cells: 6,097 nCPM
  • epididymal efferent duct absorptive cells: 4,754 nCPM
  • decidual stromal cells: 4,382 nCPM

Immune cell

  • plasmacytoid DC: 1,390 nTPM
  • gdT-cell: 51 nTPM
  • total PBMC: 11 nTPM
  • naive CD8 T-cell: 9.9 nTPM
  • memory CD8 T-cell: 6.3 nTPM
  • memory CD4 T-cell: 4.3 nTPM

Brain region

  • white matter: 3,261 nTPM
  • cerebellum: 3,086 nTPM
  • basal ganglia: 2,995 nTPM
  • medulla oblongata: 2,947 nTPM
  • thalamus: 2,682 nTPM
  • midbrain: 2,622 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0.01
gnomAD missense Z
0.53
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGDS as an antibody target. Whether an autoantibody or antibody against PTGDS could matter depends on whether native PTGDS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGDS is annotated as secreted, so native PTGDS circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PTGDS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTGDS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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