Seroatlas · Human Serome Atlas

PTCHD4

Patched domain-containing protein 4

Also known as: C6orf138, dJ402H5.2, FLJ41841, PTCH53, PTHD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZW05
Gene: PTCHD4
Ensembl: ENSG00000244694
Chromosome: 6
Canonical length: 846 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

846 residues, UniProt reviewed canonical sequence.

>Q6ZW05|PTCHD4
     1  MCFLRRPGAP ASWIWWRMLR QVLRRGLQSF CHRLGLCVSR HPVFFLTVPA VLTITFGLSA
    61  LNRFQPEGDL ERLVAPSHSL AKIERSLASS LFPLDQSKSQ LYSDLHTPGR YGRVILLSPT
   121  GDNILLQAEG ILQTHRAVLE MKDGRNSFIG HQLGGVVEVP NSKDQRVKSA RAIQITYYLQ
   181  TYGSATQDLI GEKWENEFCK LIRKLQEEHQ ELQLYSLASF SLWRDFHKTS ILARSKVLVS
   241  LVLILTTATL SSSMKDCLRS KPFLGLLGVL TVCISIITAA GIFFITDGKY NSTLLGIPFF
   301  AMGHGTKGVF ELLSGWRRTK ENLPFKDRIA DAYSDVMVTY TMTSSLYFIT FGMGASPFTN
   361  IEAVKVFCQN MCVSILLNYF YIFSFFGSCL VFAGQLEQNR YHSIFCCKIP SAEYLDRKPV
   421  WFQTVMSDGH QQTSHHETNP YQHHFIQHFL REHYNEWITN IYVKPFVVIL YLIYASFSFM
   481  GCLQISDGAN IINLLASDSP SVSYAMVQQK YFSNYSPVIG FYVYEPLEYW NSSVQDDLRR
   541  LCSGFTAVSW VEQYYQFLKV SNVSANNKSD FISVLQSSFL KKPEFQHFRN DIIFSKAGDE
   601  SNIIASRLYL VARTSRDKQK EITEVLEKLR PLSLSKSIRF IVFNPSFVFM DHYSLSVTVP
   661  VLIAGFGVLL VLILTFFLVI HPLGNFWLIL SVTSIELGVL GLMTLWNVDM DCISILCLIY
   721  TLNFAIDHCA PLLFTFVLAT EHTRTQCIKS SLQDHGTAIL QNVTSFLIGL VPLLFVPSNL
   781  TFTLFKCLLL TGGCTLLHCF VILPVFLTFF PPSKKHHKKK KRAKRKEREE IECIEIQENP
   841  DHVTTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTCHD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

seminal vesicle: 0.9 nTPM
choroid plexus: 0.8 nTPM
pituitary gland: 0.7 nTPM
retina: 0.7 nTPM
blood vessel: 0.6 nTPM
cervix: 0.6 nTPM

Single-cell type

retinal ganglion cells: 355 nCPM
brain inhibitory neurons: 269 nCPM
retinal amacrine cells: 146 nCPM
pituitary stem cells: 84 nCPM
other brain neurons: 79 nCPM
microglia: 77 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 8.2 nTPM
midbrain: 6.6 nTPM
basal ganglia: 6 nTPM
white matter: 5.9 nTPM
hypothalamus: 5.7 nTPM
spinal cord: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: -0.07
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTCHD4 as an antibody target. Whether an autoantibody or antibody against PTCHD4 could matter depends on whether native PTCHD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTCHD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTCHD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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