Seroatlas · Human Serome Atlas

PTCHD3

Patched domain-containing protein 3

Also known as: PTHD3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KNS1
Gene: PTCHD3
Canonical length: 954 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for PTCHD3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

954 residues, UniProt reviewed canonical sequence.

>Q3KNS1|PTCHD3
     1  MPWVEPKPRP GPEQKPKLTK PDSATGPQWY QESQESESEG KQPPPGPLAP PKSPEPSGPL
    61  ASEQDAPLPE GDDAPPRPSM LDDAPRLPLE LDDAPLPEEE TPEPTAICRH RHRCHTDCLE
   121  GLLSRTFQWL GWQVGAHPWI FLLAPLMLTA ALGTGFLYLP KDEEEDLEEH YTPVGSPAKA
   181  ERRFVQGHFT TNDSYRFSAS RRSTEANFVS LLVVSYSDSL LDPATFAEVS KLDGAVQDLR
   241  VAREKGSQIQ YQQVCARYRA LCVPPNPILY AWQVNKTLNL SSISFPAYNH GRHPLYLTGF
   301  FGGYILGGSL GMGQLLLRAK AMRLLYYLKT EDPEYDVQSK QWLTHLLDQF TNIKNILALK
   361  KIEVVHFTSL SRQLEFEATS VTVIPVFHLA YILIILFAVT SCFRFDCIRN KMCVAAFGVI
   421  SAFLAVVSGF GLLLHIGVPF VIIVANSPFL ILGVGVDDMF IMISAWHKTN LADDIRERMS
   481  NVYSKAAVSI TITTITNILA LYTGIMSSFR SVQCFCIYTG MTLLFCYFYN ITCFGAFMAL
   541  DGKREVVCLC WLKKADPKWP SFKKFCCFPF GSVPDEHGTD IHPISLFFRD YFGPFLTRSE
   601  SKYFVVFIYV LYIISSIYGC FHVQEGLDLR NLASDDSYIT PYFNVEENYF SDYGPRVMVI
   661  VTKKVDYWDK DVRQKLENCT KIFEKNVYVD KNLTEFWLDA YVQYLKGNSQ DPNEKNTFMN
   721  NIPDFLSNFP NFQHDINISS SNEIISSRGF IQTTDVSSSA KKKILLFQLR RIAEDCQIPL
   781  MVYNQAFIYF DQYAAILEDT VRNVLVASAA MFIVSLLLIP YPLCSLWVTF AIGSVIVGVT
   841  GFMAFWKVNL DSISMINLVI CIGFSFDFSV HISYAFVSSS QPSVNQKSVE ALYLLGYPVL
   901  QSAISTIIGV CVLAAAKAYI FRTFFKIMFL VMIFGAAHGL IFIPVFLTFF GRFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTCHD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 13
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 3.1 nTPM

Expression across tissuesHPA

Tissue

testis: 3.1 nTPM
adipose tissue: 0.6 nTPM
pancreas: 0.6 nTPM
breast: 0.2 nTPM
cervix: 0.1 nTPM
fallopian tube: 0.1 nTPM

Single-cell type

other brain neurons: 0.4 nCPM
oligodendrocyte progenitor cells: 0.3 nCPM
brain excitatory neurons: 0.1 nCPM
brain inhibitory neurons: 0.1 nCPM
early spermatids: 0.1 nCPM
microglia: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.4 nTPM
midbrain: 0.4 nTPM
cerebellum: 0.3 nTPM
cerebral cortex: 0.3 nTPM
hippocampal formation: 0.3 nTPM
medulla oblongata: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: -0.36

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTCHD3 as an antibody target. Whether an autoantibody or antibody against PTCHD3 could matter depends on whether native PTCHD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTCHD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTCHD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...