Seroatlas · Human Serome Atlas

PSPHP1

Putative phosphoserine phosphatase-like protein

Also known as: PSPHL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15172
Gene: PSPHP1
Canonical length: 72 aa

OverviewNCBI Gene

No narrative summary is available for PSPHP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

72 residues, UniProt reviewed canonical sequence.

>O15172|PSPHP1
     1  MASASCSPGG ALASPEPGRK ILPRMISHSE LRKLFYSADA VCFDVDSTVI SEEGIGCFHW
    61  IWRKCDQATS QG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSPHP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSPHP1 as an antibody target. Whether an autoantibody or antibody against PSPHP1 could matter depends on whether native PSPHP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSPHP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSPHP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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