Seroatlas · Human Serome Atlas

PSORS1C2

Psoriasis susceptibility 1 candidate gene 2 protein

Also known as: C6orf17, PS1C2_HUMAN, SPR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UIG4
Gene
PSORS1C2
Ensembl
ENSG00000204538
Chromosome
6
Canonical length
136 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>Q9UIG4|PSORS1C2
     1  MILNWKLLGI LVLCLHTRGI SGSEGHPSHP PAEDREEAGS PTLPQGPPVP GDPWPGAPPL
    61  FEDPPPTRPS RPWRDLPETG VWLPEPPRTD PPQPPRPDDP WPAGPQPPEN PWPPAPEVDN
   121  RPQEEPDLDP PREEYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSORS1C2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
250 nTPM

Expression across tissuesHPA

Tissue

  • skin: 250 nTPM
  • esophagus: 4.4 nTPM
  • salivary gland: 2.5 nTPM
  • testis: 2.2 nTPM
  • adipose tissue: 2 nTPM
  • vagina: 1.9 nTPM

Single-cell type

  • endometrial luminal cells: 2.5 nCPM
  • endometrial glandular cells: 1 nCPM
  • esophageal apical cells: 0.5 nCPM
  • endometrial ciliated cells: 0.2 nCPM
  • endometrial stromal cells: 0.1 nCPM
  • esophageal suprabasal cells: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0
gnomAD missense Z
0.26
DepMap mean gene effect
0.17
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Psoriasis susceptibility 1 candidate gene 2 protein
  • Psoriasis susceptibility locus 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSORS1C2 as an antibody target. Whether an autoantibody or antibody against PSORS1C2 could matter depends on whether native PSORS1C2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSORS1C2 is annotated as secreted, so native PSORS1C2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSORS1C2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSORS1C2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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