PSORS1C1
Psoriasis susceptibility 1 candidate gene 1 protein
Also known as: C6orf16, PS1C1_HUMAN, SEEK1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UIG5
- Gene
- PSORS1C1
- Ensembl
- ENSG00000204540
- Chromosome
- 6
- Canonical length
- 152 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene is one of several genes thought to confer susceptibility to psoriasis and systemic sclerosis, located on chromosome 6 near the major histocompatibility complex (MHC) class I region. [provided by RefSeq, Sep 2011]
Canonical amino-acid sequenceUniProt
152 residues, UniProt reviewed canonical sequence.
>Q9UIG5|PSORS1C1
1 MTCTDQKSHS QRALGTQTPA LQGPQLLNTD PSSEETRPPH VNPDRLCHME PANHFWHAGD
61 LQAMISKEFH LAATQDDCRK GRTQEDILVP SSHPELFASV LPMAPEEAAR LQQPQPLPPP
121 SGIHLSASRT LAPTLLYSSP PSHSPFGLSS LILocalizationUniProt · AlphaFold · HPA
Whether an antibody against PSORS1C1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
- Highest tissue expression
- 106 nTPM
Expression across tissuesHPA
Tissue
- testis: 106 nTPM
- skin: 3.1 nTPM
- epididymis: 2.2 nTPM
- small intestine: 1.8 nTPM
- blood vessel: 1.6 nTPM
- lung: 1.6 nTPM
Single-cell type
- late spermatids: 419 nCPM
- early spermatids: 86 nCPM
- late primary spermatocytes: 78 nCPM
- epididymal efferent duct absorptive cells: 16 nCPM
- early primary spermatocytes: 16 nCPM
- epididymal efferent duct ciliated cells: 16 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.2 nTPM
- amygdala: 0.1 nTPM
- basal ganglia: 0.1 nTPM
- hypothalamus: 0.1 nTPM
- medulla oblongata: 0.1 nTPM
- pons: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.87
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.68
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Psoriasis susceptibility 1 candidate 1
- Psoriasis susceptibility 1 candidate 1
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PSORS1C1 as an antibody target. Whether an autoantibody or antibody against PSORS1C1 could matter depends on whether native PSORS1C1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PSORS1C1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PSORS1C1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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