Seroatlas · Human Serome Atlas

PSMB11

Proteasome subunit beta type-11

Also known as: beta5t, PSB11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A5LHX3
Gene
PSMB11
Ensembl
ENSG00000222028
Chromosome
14
Canonical length
300 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>A5LHX3|PSMB11
     1  MALQDVCKWQ SPDTQGPSPH LPRAGGWAVP RGCDPQTFLQ IHGPRLAHGT TTLAFRFRHG
    61  VIAAADTRSS CGSYVACPAS CKVIPVHQHL LGTTSGTSAD CATWYRVLQR ELRLRELREG
   121  QLPSVASAAK LLSAMMSQYR GLDLCVATAL CGWDRSGPEL FYVYSDGTRL QGDIFSVGSG
   181  SPYAYGVLDR GYRYDMSTQE AYALARCAVA HATHRDAYSG GSVDLFHVRE SGWEHVSRSD
   241  ACVLYVELQK LLEPEPEEDA SHAHPEPATA HRAAEDRELS VGPGEVTPGD SRMPAGTETV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMB11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 29 nTPM
  • testis: 0.3 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late spermatids: 3.7 nCPM
  • late primary spermatocytes: 2.6 nCPM
  • early spermatids: 1.3 nCPM
  • epididymal basal cells: 0.2 nCPM
  • undifferentiated spermatogonia: 0.2 nCPM
  • astrocytes: 0.1 nCPM

Immune cell

  • naive CD4 T-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMB11 as an antibody target. Whether an autoantibody or antibody against PSMB11 could matter depends on whether native PSMB11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMB11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMB11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMB11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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