Seroatlas · Human Serome Atlas

PSKH1

Serine/threonine-protein kinase H1

Also known as: KPSH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11801
Gene
PSKH1
Ensembl
ENSG00000159792
Chromosome
16
Canonical length
424 aa
Protein class
Enzymes, Predicted membrane proteins
Subcellular location
Nuclear speckles,Plasma membrane,Primary cilium,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within determination of left/right symmetry; heart development; and protein phosphorylation. Located in several cellular components, including cilium; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>P11801|PSKH1
     1  MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPVKA GFPAASQYAH
    61  PCPGPPTAGH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI KALIGRGSFS RVVRVEHRAT
   121  RQPYAIKMIE TKYREGREVC ESELRVLRRV RHANIIQLVE VFETQERVYM VMELATGGEL
   181  FDRIIAKGSF TERDATRVLQ MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF
   241  GLASARKKGD DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD
   301  NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL RHPWVVSMAA
   361  SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS NKSRRVRERE LRELNLRYQQ
   421  QYNG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSKH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 31 nTPM
  • pancreas: 25 nTPM
  • kidney: 23 nTPM
  • testis: 21 nTPM
  • stomach: 20 nTPM
  • blood vessel: 18 nTPM

Single-cell type

  • myonuclei: 51 nCPM
  • choroid plexus epithelial cells: 35 nCPM
  • cone photoreceptor cells: 33 nCPM
  • retinal bipolar cells: 31 nCPM
  • megakaryocytes: 31 nCPM
  • late spermatids: 30 nCPM

Immune cell

  • intermediate monocyte: 2.2 nTPM
  • myeloid DC: 2.1 nTPM
  • NK-cell: 2.1 nTPM
  • classical monocyte: 2 nTPM
  • gdT-cell: 2 nTPM
  • memory CD8 T-cell: 2 nTPM

Brain region

  • choroid plexus: 35 nTPM
  • medulla oblongata: 26 nTPM
  • midbrain: 25 nTPM
  • white matter: 24 nTPM
  • basal ganglia: 24 nTPM
  • cerebral cortex: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSKH1.

Disease | AllUniProt

Conditions PSKH1 is implicated in, by any mechanism.

  • Cholestasis, progressive familial intrahepatic, 13 (PFIC13) MIM:620962

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 66 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cholestasis, progressive familial intrahepatic, 13

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.26
gnomAD missense Z
2.28
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSKH1 as an antibody target. Whether an autoantibody or antibody against PSKH1 could matter depends on whether native PSKH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSKH1 is annotated at the cell surface, where native PSKH1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PSKH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSKH1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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