Seroatlas · Human Serome Atlas

PSD2

PH and SEC7 domain-containing protein 2

Also known as: DKFZp761B0514, EFA6C, PSD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BQI7
Gene
PSD2
Ensembl
ENSG00000146005
Chromosome
5
Canonical length
771 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in cleavage furrow and ruffle membrane. Predicted to be active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

771 residues, UniProt reviewed canonical sequence.

>Q9BQI7|PSD2
     1  MEEDKLLSAV PEEGDATRDP GPEPEEEPGV RNGMASEGLN SSLCSPGHER RGTPADTEEP
    61  TKDPDVAFHG LSLGLSLTNG LALGPDLNIL EDSAESRPWR AGVLAEGDNA SRSLYPDAED
   121  PQLGLDGPGE PDVRDGFSAT FEKILESELL RGTQYSSLDS LDGLSLTDES DSCVSFEAPL
   181  TPLIQQRARD SPEPGAGLGI GDMAFEGDMG AAGGDGELGS PLRRSISSSR SENVLSRLSL
   241  MAMPNGFHED GPQGPGGDED DDEEDTDKLL NSASDPSLKD GLSDSDSELS SSEGLEPGSA
   301  DPLANGCQGV SEAAHRLARR LYHLEGFQRC DVARQLGKNN EFSRLVAGEY LSFFDFSGLT
   361  LDGALRTFLK AFPLMGETQE RERVLTHFSR RYCQCNPDDS TSEDGIHTLT CALMLLNTDL
   421  HGHNIGKKMS CQQFIANLDQ LNDGQDFAKD LLKTLYNSIK NEKLEWAIDE DELRKSLSEL
   481  VDDKFGTGTK KVTRILDGGN PFLDVPQALS ATTYKHGVLT RKTHADMDGK RTPRGRRGWK
   541  KFYAVLKGTI LYLQKDEYRP DKALSEGDLK NAIRVHHALA TRASDYSKKS NVLKLKTADW
   601  RVFLFQAPSK EEMLSWILRI NLVAAIFSAP AFPAAVSSMK KFCRPLLPSC TTRLCQEEQL
   661  RSHENKLRQL TAELAEHRCH PVERGIKSKE AEEYRLKEHY LTFEKSRYET YIHLLAMKIK
   721  VGSDDLERIE ARLATLEGDD PSLRKTHSSP ALSQGHVTGS KTTKDATGPD T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 82 nTPM
  • cerebral cortex: 58 nTPM
  • amygdala: 57 nTPM
  • midbrain: 55 nTPM
  • hypothalamus: 45 nTPM
  • cerebellum: 40 nTPM

Single-cell type

  • astrocytes: 253 nCPM
  • ependymal cells: 128 nCPM
  • bergmann glia: 124 nCPM
  • oligodendrocyte progenitor cells: 66 nCPM
  • other brain neurons: 15 nCPM
  • retinal amacrine cells: 11 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 208 nTPM
  • midbrain: 203 nTPM
  • medulla oblongata: 171 nTPM
  • basal ganglia: 170 nTPM
  • cerebellum: 162 nTPM
  • pons: 148 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSD2 as an antibody target. Whether an autoantibody or antibody against PSD2 could matter depends on whether native PSD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSD2 is annotated at the cell surface, where native PSD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PSD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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