Seroatlas · Human Serome Atlas

PSCA

Prostate stem cell antigen

Also known as: lncPSCA, PSCA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43653
Gene
PSCA
Ensembl
ENSG00000167653
Chromosome
8
Canonical length
114 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>O43653|PSCA
     1  MAGLALQPGT ALLCYSCKAQ VSNEDCLQVE NCTQLGEQCW TARIRAVGLL TVISKGCSLN
    61  CVDDSQDYYV GKKNITCCDT DLCNASGAHA LQPAAAILAL LPALGLLLWG PGQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSCA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
3,010 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 3,010 nTPM
  • urinary bladder: 569 nTPM
  • esophagus: 341 nTPM
  • prostate: 217 nTPM
  • vagina: 166 nTPM
  • cervix: 129 nTPM

Single-cell type

  • parietal cells: 10,611 nCPM
  • esophageal apical cells: 9,592 nCPM
  • foveolar cells: 7,559 nCPM
  • prostatic club cells: 3,522 nCPM
  • salivary duct cells: 1,371 nCPM
  • gastric chief cells: 1,232 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.4 nTPM
  • hippocampal formation: 0.9 nTPM
  • amygdala: 0.8 nTPM
  • pons: 0.8 nTPM
  • white matter: 0.8 nTPM
  • basal ganglia: 0.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSCA.

Disease | ImmuneIEDB

Conditions an epitope on PSCA was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.66
gnomAD pLI
0.17
gnomAD missense Z
-0.15
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSCA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSCA as an antibody target. Whether an autoantibody or antibody against PSCA could matter depends on whether native PSCA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSCA is annotated at the cell surface, where native PSCA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PSCA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSCA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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