Seroatlas · Human Serome Atlas

PSAPL1

Proactivator polypeptide-like 1

Also known as: SAPL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NUJ1
Gene: PSAPL1
Ensembl: ENSG00000178597
Chromosome: 4
Canonical length: 521 aa
Protein class: Predicted secreted proteins
Subcellular location: Cytosol
Secretome location: Secreted - unknown location

OverviewNCBI Gene

This gene encodes a protein that is related to the glycoprotein prosaposin. Based on sequence similarity between the encoded protein and prosaposin, it is predicted that the encoded protein is a preproprotein that is proteolytically processed to generate multiple protein products. These predicted products include saposins A-like, B-like, C-like, and D-like, which may play a role in the lysosomal degradation of sphingolipids. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

521 residues, UniProt reviewed canonical sequence.

>Q6NUJ1|PSAPL1
     1  MLCALLLLPS LLGATRASPT SGPQECAKGS TVWCQDLQTA ARCGAVGYCQ GAVWNKPTAK
    61  SLPCDVCQDI AAAAGNGLNP DATESDILAL VMKTCEWLPS QESSAGCKWM VDAHSSAILS
   121  MLRGAPDSAP AQVCTALSLC EPLQRHLATL RPLSKEDTFE AVAPFMANGP LTFHPRQAPE
   181  GALCQDCVRQ VSRLQEAVRS NLTLADLNIQ EQCESLGPGL AVLCKNYLFQ FFVPADQALR
   241  LLPPQELCRK GGFCEELGAP ARLTQVVAMD GVPSLELGLP RKQSEMQMKA GVTCEVCMNV
   301  VQKLDHWLMS NSSELMITHA LERVCSVMPA SITKECIILV DTYSPSLVQL VAKITPEKVC
   361  KFIRLCGNRR RARAVHDAYA IVPSPEWDAE NQGSFCNGCK RLLTVSSHNL ESKSTKRDIL
   421  VAFKGGCSIL PLPYMIQCKH FVTQYEPVLI ESLKDMMDPV AVCKKVGACH GPRTPLLGTD
   481  QCALGPSFWC RSQEAAKLCN AVQHCQKHVW KEMHLHAGEH A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSAPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

skin: 96 nTPM
stomach: 36 nTPM
breast: 4.6 nTPM
testis: 3.4 nTPM
tonsil: 2.9 nTPM
adipose tissue: 0.3 nTPM

Single-cell type

foveolar cells: 543 nCPM
mucous neck cells: 3.9 nCPM
mesothelial cells: 2.8 nCPM
gastric chief cells: 2.2 nCPM
parietal cells: 1.8 nCPM
gastric progenitor cells: 1.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 2.6 nTPM
basal ganglia: 2.2 nTPM
cerebral cortex: 2.2 nTPM
medulla oblongata: 2.1 nTPM
pons: 2 nTPM
thalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.01
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSAPL1 as an antibody target. Whether an autoantibody or antibody against PSAPL1 could matter depends on whether native PSAPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSAPL1 is annotated as secreted, so native PSAPL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSAPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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