Seroatlas · Human Serome Atlas

PRY

PTPN13-like protein, Y-linked

Also known as: PRY_HUMAN, PRY1, PRY2, PTPN13LY, PTPN13LY2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14603
Gene
PRY
Ensembl
ENSG00000169789
Chromosome
Y
Canonical length
147 aa
Protein class
Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more telomeric copy. [provided by RefSeq, Aug 2024]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>O14603|PRY
     1  MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE LSLNRGLEAR RKKDLKDSFL
    61  WRYGKVGCIS LPLREMTAWI NPPQISEIFQ GYHQRVHGAD ALSLQTNSLR SRLSSQCLGQ
   121  SFLLRTLERG RGFRALGDIC GHVHEED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
1.1 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 1.1 nTPM
  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late primary spermatocytes: 0.6 nCPM
  • early spermatids: 0.3 nCPM
  • renal collecting duct intercalated cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM

Immune cell

  • memory CD4 T-cell: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hypothalamus: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • midbrain: 0.1 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRY as an antibody target. Whether an autoantibody or antibody against PRY could matter depends on whether native PRY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRY. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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