Seroatlas · Human Serome Atlas

PRXL2A

Peroxiredoxin-like 2A

Also known as: Adrx, C10orf58, FAM213A, MGC4248, PAMM, PXL2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRX8
Gene: PRXL2A
Ensembl: ENSG00000122378
Chromosome: 10
Canonical length: 229 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Enables antioxidant activity. Involved in regulation of osteoclast differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q9BRX8|PRXL2A
     1  MSFLQDPSFF TMGMWSIGAG ALGAAALALL LANTDVFLSK PQKAALEYLE DIDLKTLEKE
    61  PRTFKAKELW EKNGAVIMAV RRPGCFLCRE EAADLSSLKS MLDQLGVPLY AVVKEHIRTE
   121  VKDFQPYFKG EIFLDEKKKF YGPQRRKMMF MGFIRLGVWY NFFRAWNGGF SGNLEGEGFI
   181  LGGVFVVGSG KQGILLEHRE KEFGDKVNLL SVLEAAKMIK PQTLASEKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRXL2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 381 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 381 nTPM
breast: 207 nTPM
epididymis: 201 nTPM
liver: 184 nTPM
cerebral cortex: 171 nTPM
choroid plexus: 167 nTPM

Single-cell type

retinal pigment epithelial cells: 763 nCPM
epididymal principal cells: 640 nCPM
esophageal basal cells: 606 nCPM
esophageal suprabasal cells: 376 nCPM
endometrial luminal cells: 360 nCPM
urothelial cells: 325 nCPM

Immune cell

plasmacytoid DC: 166 nTPM
memory B-cell: 16 nTPM
naive CD8 T-cell: 14 nTPM
naive CD4 T-cell: 14 nTPM
eosinophil: 12 nTPM
naive B-cell: 11 nTPM

Brain region

thalamus: 191 nTPM
choroid plexus: 168 nTPM
hippocampal formation: 166 nTPM
amygdala: 147 nTPM
midbrain: 146 nTPM
cerebral cortex: 145 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of osteoclast differentiation

Molecular functions

antioxidant activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRXL2A as an antibody target. Whether an autoantibody or antibody against PRXL2A could matter depends on whether native PRXL2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRXL2A is annotated as secreted, so native PRXL2A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRXL2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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