Seroatlas · Human Serome Atlas

PRTG

Protogenin

Also known as: FLJ25756, IGDCC5, PRTG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2VWP7
Gene
PRTG
Ensembl
ENSG00000166450
Chromosome
15
Canonical length
1150 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

1150 residues, UniProt reviewed canonical sequence.

>Q2VWP7|PRTG
     1  MAPPLRPLAR LRPPGMLLRA LLLLLLLSPL PGVWCFSELS FVKEPQDVTV TRKDPVVLDC
    61  QAHGEVPIKV TWLKNGAKMS ENKRIEVLSN GSLYISEVEG RRGEQSDEGF YQCLAMNKYG
   121  AILSQKAHLA LSTISAFEVQ PISTEVHEGG VARFACKISS HPPAVITWEF NRTTLPMTMD
   181  RITALPTGVL QIYDVSQRDS GNYRCIAATV AHRRKSMEAS LTVIPAKESK SFHTPTIIAG
   241  PQNITTSLHQ TVVLECMATG NPKPIISWSR LDHKSIDVFN TRVLGNGNLM ISDVRLQHAG
   301  VYVCRATTPG TRNFTVAMAT LTVLAPPSFV EWPESLTRPR AGTARFVCQA EGIPSPKMSW
   361  LKNGRKIHSN GRIKMYNSKL VINQIIPEDD AIYQCMAENS QGSILSRARL TVVMSEDRPS
   421  APYNVHAETM SSSAILLAWE RPLYNSDKVI AYSVHYMKAE GLNNEEYQVV IGNDTTHYII
   481  DDLEPASNYT FYIVAYMPMG ASQMSDHVTQ NTLEDVPLRP PEISLTSRSP TDILISWLPI
   541  PAKYRRGQVV LYRLSFRLST ENSIQVLELP GTTHEYLLEG LKPDSVYLVR ITAATRVGLG
   601  ESSVWTSHRT PKATSVKAPK SPELHLEPLN CTTISVRWQQ DVEDTAAIQG YKLYYKEEGQ
   661  QENGPIFLDT KDLLYTLSGL DPRRKYHVRL LAYNNIDDGY QADQTVSTPG CVSVRDRMVP
   721  PPPPPHHLYA KANTSSSIFL HWRRPAFTAA QIINYTIRCN PVGLQNASLV LYLQTSETHM
   781  LVQGLEPNTK YEFAVRLHVD QLSSPWSPVV YHSTLPEAPA GPPVGVKVTL IEDDTALVSW
   841  KPPDGPETVV TRYTILYASR KAWIAGEWQV LHREGAITMA LLENLVAGNV YIVKISASNE
   901  VGEGPFSNSV ELAVLPKETS ESNQRPKRLD SADAKVYSGY YHLDQKSMTG IAVGVGIALT
   961  CILICVLILI YRSKARKSSA SKTAQNGTQQ LPRTSASLAS GNEVGKNLEG AVGNEESLMP
  1021  MIMPNSFIDA KGGTDLIINS YGPIIKNNSK KKWFFFQDSK KIQVEQPQRR FTPAVCFYQP
  1081  GTTVLISDED SPSSPGQTTS FSRPFGVAAD TEHSANSEGS HETGDSGRFS HESNDEIHLS
  1141  SVISTTPPNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRTG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 10 nTPM
  • retina: 9.6 nTPM
  • endometrium: 3.4 nTPM
  • testis: 3.3 nTPM
  • placenta: 2.6 nTPM
  • ovary: 1.8 nTPM

Single-cell type

  • cone photoreceptor cells: 288 nCPM
  • rod photoreceptor cells: 184 nCPM
  • bergmann glia: 173 nCPM
  • renal collecting duct principal cells: 148 nCPM
  • alveolar cells type 2: 126 nCPM
  • renal connecting tubule cells: 105 nCPM

Immune cell

  • non-classical monocyte: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 12 nTPM
  • medulla oblongata: 9.6 nTPM
  • spinal cord: 8.1 nTPM
  • thalamus: 7.9 nTPM
  • hypothalamus: 7.7 nTPM
  • midbrain: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0
gnomAD missense Z
0.39
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRTG as an antibody target. Whether an autoantibody or antibody against PRTG could matter depends on whether native PRTG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRTG is annotated at the cell surface, where native PRTG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRTG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRTG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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