Seroatlas · Human Serome Atlas

PRSS8

Prostasin

Also known as: CAP1, PRSS8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16651
Gene
PRSS8
Ensembl
ENSG00000052344
Chromosome
16
Canonical length
343 aa
Protein class
Enzymes, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q16651|PRSS8
     1  MAQKGVLGPG QLGAVAILLY LGLLRSGTGA EGAEAPCGVA PQARITGGSS AVAGQWPWQV
    61  SITYEGVHVC GGSLVSEQWV LSAAHCFPSE HHKEAYEVKL GAHQLDSYSE DAKVSTLKDI
   121  IPHPSYLQEG SQGDIALLQL SRPITFSRYI RPICLPAANA SFPNGLHCTV TGWGHVAPSV
   181  SLLTPKPLQQ LEVPLISRET CNCLYNIDAK PEEPHFVQED MVCAGYVEGG KDACQGDSGG
   241  PLSCPVEGLW YLTGIVSWGD ACGARNRPGV YTLASSYASW IQSKVTELQP RVVPQTQESQ
   301  PDSNLCGSHL AFSSAPAQGL LRPILFLPLG LALGLLSPWL SEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
231 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 231 nTPM
  • stomach: 152 nTPM
  • duodenum: 147 nTPM
  • small intestine: 144 nTPM
  • esophagus: 134 nTPM
  • pancreas: 132 nTPM

Single-cell type

  • extravillous trophoblasts: 1,024 nCPM
  • esophageal apical cells: 887 nCPM
  • syncytiotrophoblasts: 689 nCPM
  • enterocytes: 336 nCPM
  • epididymal principal cells: 321 nCPM
  • migrating cytotrophoblasts: 313 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • cerebellum: 5 nTPM
  • cerebral cortex: 2 nTPM
  • hippocampal formation: 1.8 nTPM
  • basal ganglia: 1.5 nTPM
  • pons: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.1
gnomAD missense Z
1.17
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS8 as an antibody target. Whether an autoantibody or antibody against PRSS8 could matter depends on whether native PRSS8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS8 is annotated at the cell surface, where native PRSS8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRSS8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRSS8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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