PRSS58
Serine protease 58
Also known as: PRS58_HUMAN, TRYX3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IYP2
- Gene
- PRSS58
- Ensembl
- ENSG00000258223
- Chromosome
- 7
- Canonical length
- 241 aa
- Protein class
- Enzymes, Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as a trypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
241 residues, UniProt reviewed canonical sequence.
>Q8IYP2|PRSS58
1 MKFILLWALL NLTVALAFNP DYTVSSTPPY LVYLKSDYLP CAGVLIHPLW VITAAHCNLP
61 KLRVILGVTI PADSNEKHLQ VIGYEKMIHH PHFSVTSIDH DIMLIKLKTE AELNDYVKLA
121 NLPYQTISEN TMCSVSTWSY NVCDIYKEPD SLQTVNISVI SKPQCRDAYK TYNITENMLC
181 VGIVPGRRQP CKEVSAAPAI CNGMLQGILS FADGCVLRAD VGIYAKIFYY IPWIENVIQN
241 NLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRSS58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- testis: 24 nTPM
- pancreas: 0.1 nTPM
- thymus: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- early spermatids: 750 nCPM
- late spermatids: 257 nCPM
- late primary spermatocytes: 12 nCPM
- sertoli cells: 3.4 nCPM
- leydig cells: 1.2 nCPM
- peritubular myoid cells: 1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- pons: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.8
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.54
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRSS58 as an antibody target. Whether an autoantibody or antibody against PRSS58 could matter depends on whether native PRSS58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRSS58 is annotated as secreted, so native PRSS58 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PRSS58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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