Seroatlas · Human Serome Atlas

PRSS56

Serine protease 56

Also known as: PRS56_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CW18
Gene
PRSS56
Ensembl
ENSG00000237412
Chromosome
2
Canonical length
603 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that contains a peptidase S1 domain and possesses trypsin-like serine protease activity. The encoded protein may play a role in eye development, and mutations in this gene are a cause of autosomal recessive posterior microphthalmos. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

603 residues, UniProt reviewed canonical sequence.

>P0CW18|PRSS56
     1  MLLAVLLLLP LPSSWFAHGH PLYTRLPPSA LQVLSAQGTQ ALQAAQRSAQ WAINRVAMEI
    61  QHRSHECRGS GRPRPQALLQ DPPEPGPCGE RRPSTANVTR AHGRIVGGSA APPGAWPWLV
   121  RLQLGGQPLC GGVLVAASWV LTAAHCFVGA PNELLWTVTL AEGSRGEQAE EVPVNRILPH
   181  PKFDPRTFHN DLALVQLWTP VSPGGSARPV CLPQEPQEPP AGTACAIAGW GALFEDGPEA
   241  EAVREARVPL LSTDTCRRAL GPGLRPSTML CAGYLAGGVD SCQGDSGGPL TCSEPGPRPR
   301  EVLFGVTSWG DGCGEPGKPG VYTRVAVFKD WLQEQMSASS SREPSCRELL AWDPPQELQA
   361  DAARLCAFYA RLCPGSQGAC ARLAHQQCLQ RRRRCELRSL AHTLLGLLRN AQELLGPRPG
   421  LRRLAPALAL PAPALRESPL HPARELRLHS GSRAAGTRFP KRRPEPRGEA NGCPGLEPLR
   481  QKLAALQGAH AWILQVPSEH LAMNFHEVLA DLGSKTLTGL FRAWVRAGLG GRHVAFSGLV
   541  GLEPATLARS LPRLLVQALQ AFRVAALAEG EPEGPWMDVG QGPGLERKGH HPLNPQVPPA
   601  RQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS56 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
9.1 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 9.1 nTPM
  • retina: 4.9 nTPM
  • hypothalamus: 2.4 nTPM
  • testis: 1.8 nTPM
  • basal ganglia: 1 nTPM
  • midbrain: 1 nTPM

Single-cell type

  • müller glia: 50 nCPM
  • early spermatids: 37 nCPM
  • epididymal efferent duct ciliated cells: 8 nCPM
  • other brain neurons: 6.1 nCPM
  • myonuclei: 4.2 nCPM
  • late spermatids: 3.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 9.6 nTPM
  • hypothalamus: 6.9 nTPM
  • pons: 6.6 nTPM
  • medulla oblongata: 6.1 nTPM
  • cerebellum: 3.7 nTPM
  • thalamus: 3.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRSS56.

Disease | AllUniProt

Conditions PRSS56 is implicated in, by any mechanism.

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 265 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
1.05

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS56 as an antibody target. Whether an autoantibody or antibody against PRSS56 could matter depends on whether native PRSS56 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS56 is annotated as secreted, so native PRSS56 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS56 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRSS56. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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