PRSS55
Serine protease 55
Also known as: CT153, PRS55_HUMAN, T-SP1, UNQ9391
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UWB4
- Gene
- PRSS55
- Ensembl
- ENSG00000184647
- Chromosome
- 8
- Canonical length
- 352 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Acrosome
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
This gene encodes a member of a group of membrane-anchored chymotrypsin (S1)-like serine proteases. The enocoded protein is primarily expressed in the Leydig and Sertoli cells of the testis and may be involved in male fertility. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Canonical amino-acid sequenceUniProt
352 residues, UniProt reviewed canonical sequence.
>Q6UWB4|PRSS55
1 MLLFSVLLLL SLVTGTQLGP RTPLPEAGVA ILGRARGAHR PQPPHPPSPV SECGDRSIFE
61 GRTRYSRITG GMEAEVGEFP WQVSIQARSE PFCGGSILNK WWILTAAHCL YSEELFPEEL
121 SVVLGTNDLT SPSMEIKEVA SIILHKDFKR ANMDNDIALL LLASPIKLDD LKVPICLPTQ
181 PGPATWRECW VAGWGQTNAA DKNSVKTDLM KAPMVIMDWE ECSKMFPKLT KNMLCAGYKN
241 ESYDACKGDS GGPLVCTPEP GEKWYQVGII SWGKSCGEKN TPGIYTSLVN YNLWIEKVTQ
301 LEGRPFNAEK RRTSVKQKPM GSPVSGVPEP GSPRSWLLLC PLSHVLFRAI LYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRSS55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 26 nTPM
Expression across tissuesHPA
Tissue
- testis: 26 nTPM
- cerebellum: 0.4 nTPM
- kidney: 0.4 nTPM
- amygdala: 0.2 nTPM
- basal ganglia: 0.2 nTPM
- cerebral cortex: 0.2 nTPM
Single-cell type
- early spermatids: 174 nCPM
- late primary spermatocytes: 102 nCPM
- late spermatids: 50 nCPM
- proximal tubule cells: 10 nCPM
- oligodendrocyte progenitor cells: 3.5 nCPM
- choroid plexus epithelial cells: 3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 1 nTPM
- hippocampal formation: 0.5 nTPM
- thalamus: 0.4 nTPM
- amygdala: 0.3 nTPM
- medulla oblongata: 0.3 nTPM
- midbrain: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.88
- gnomAD pLI
- 0
- gnomAD missense Z
- -3.4
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRSS55 as an antibody target. Whether an autoantibody or antibody against PRSS55 could matter depends on whether native PRSS55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRSS55 is annotated at the cell surface, where native PRSS55 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PRSS55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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