PRSS54
Inactive serine protease 54
Also known as: CT67, FLJ25339, KLKBL4, PRS54_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6PEW0
- Gene
- PRSS54
- Ensembl
- ENSG00000103023
- Chromosome
- 16
- Canonical length
- 395 aa
- Protein class
- Enzymes, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
This gene encodes a putative serine-type endopeptidase containing the peptidase S1 domain. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Canonical amino-acid sequenceUniProt
395 residues, UniProt reviewed canonical sequence.
>Q6PEW0|PRSS54
1 MVSAAGLSGD GKMRGVLLVL LGLLYSSTSC GVQKASVFYG PDPKEGLVSS MEFPWVVSLQ
61 DSQYTHLAFG CILSEFWVLS IASAIQNRKD IVVIVGISNM DPSKIAHTEY PVNTIIIHED
121 FDNNSMSNNI ALLKTDTAMH FGNLVQSICF LGRMLHTPPV LQNCWVSGWN PTSATGNHMT
181 MSVLRKIFVK DLDMCPLYKL QKTECGSHTK EETKTACLGD PGSPMMCQLQ QFDLWVLRGV
241 LNFGGETCPG LFLYTKVEDY SKWITSKAER AGPPLSSLHH WEKLISFSHH GPNATMTQKT
301 YSDSELGHVG SYLQGQRRTI THSRLGNSSR DSLDVREKDV KESGRSPEAS VQPLYYDYYG
361 GEVGEGRIFA GQNRLYQPEE IILVSFVLVF FCSSILocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRSS54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 39 nTPM
Expression across tissuesHPA
Tissue
- testis: 39 nTPM
- basal ganglia: 0.1 nTPM
- retina: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- early spermatids: 675 nCPM
- late spermatids: 291 nCPM
- late primary spermatocytes: 247 nCPM
- fallopian tube ciliated cells: 18 nCPM
- respiratory ciliated cells: 15 nCPM
- endometrial ciliated cells: 5.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 1.7 nTPM
- hippocampal formation: 1.2 nTPM
- choroid plexus: 1.1 nTPM
- midbrain: 1.1 nTPM
- spinal cord: 1.1 nTPM
- white matter: 1.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.86
- gnomAD pLI
- 0.1
- gnomAD missense Z
- 0.49
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRSS54 as an antibody target. Whether an autoantibody or antibody against PRSS54 could matter depends on whether native PRSS54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRSS54 is annotated as secreted, so native PRSS54 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PRSS54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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