Seroatlas · Human Serome Atlas

PRSS53

Serine protease 53

Also known as: POL3S, PRS53_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2L4Q9
Gene: PRSS53
Ensembl: ENSG00000151006
Chromosome: 16
Canonical length: 553 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q2L4Q9|PRSS53
     1  MKWCWGPVLL IAGATVLMEG LQAAQRACGQ RGPGPPKPQE GNTVPGEWPW QASVRRQGAH
    61  ICSGSLVADT WVLTAAHCFE KAAATELNSW SVVLGSLQRE GLSPGAEEVG VAALQLPRAY
   121  NHYSQGSDLA LLQLAHPTTH TPLCLPQPAH RFPFGASCWA TGWDQDTSDA PGTLRNLRLR
   181  LISRPTCNCI YNQLHQRHLS NPARPGMLCG GPQPGVQGPC QGDSGGPVLC LEPDGHWVQA
   241  GIISFASSCA QEDAPVLLTN TAAHSSWLQA RVQGAAFLAQ SPETPEMSDE DSCVACGSLR
   301  TAGPQAGAPS PWPWEARLMH QGQLACGGAL VSEEAVLTAA HCFIGRQAPE EWSVGLGTRP
   361  EEWGLKQLIL HGAYTHPEGG YDMALLLLAQ PVTLGASLRP LCLPYPDHHL PDGERGWVLG
   421  RARPGAGISS LQTVPVTLLG PRACSRLHAA PGGDGSPILP GMVCTSAVGE LPSCEGLSGA
   481  PLVHEVRGTW FLAGLHSFGD ACQGPARPAV FTALPAYEDW VSSLDWQVYF AEEPEPEAEP
   541  GSCLANISQP TSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 9.8 nTPM

Expression across tissuesHPA

Tissue

liver: 9.8 nTPM
skin: 2.4 nTPM
cerebellum: 2.3 nTPM
prostate: 0.9 nTPM
blood vessel: 0.7 nTPM
kidney: 0.7 nTPM

Single-cell type

brain excitatory neurons: 5.5 nCPM
brain inhibitory neurons: 5 nCPM
other brain neurons: 4 nCPM
astrocytes: 3.4 nCPM
oligodendrocytes: 3.4 nCPM
microglia: 2.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1 nTPM
cerebral cortex: 0.8 nTPM
hippocampal formation: 0.8 nTPM
hypothalamus: 0.8 nTPM
medulla oblongata: 0.7 nTPM
pons: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS53 as an antibody target. Whether an autoantibody or antibody against PRSS53 could matter depends on whether native PRSS53 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS53 is annotated as secreted, so native PRSS53 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS53 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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