Seroatlas · Human Serome Atlas

PRSS51

Serine protease-like protein 51

Also known as: PRS51_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1B0GVH4
Gene: PRSS51
Ensembl: ENSG00000253649
Chromosome: 8
Canonical length: 220 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>A0A1B0GVH4|PRSS51
     1  MFQLLIPLLL ALKGHAQDNP ENVQCGHRPA FPNSSWLPFH ERLQVQNGEC PWQVSIQMSR
    61  KHLCGGSILH WWWVLTAAHC FRRTLLDMAV VNVTVVMGTR TFSNIHSERK QVQKEEERTW
   121  DWCWMAQWVT TNGYDQYDDL NMHLEKLRVV QISRKECAKR INQLSRNMIC AWNEPGTNGI
   181  FKVLTPAQPP PPSRETVGHL WFVLFMEPRD SSKWVSSVGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 18 nTPM
testis: 1.2 nTPM
cerebral cortex: 1.1 nTPM
breast: 1 nTPM
retina: 0.7 nTPM
liver: 0.6 nTPM

Single-cell type

brain excitatory neurons: 28 nCPM
adipocytes: 16 nCPM
epicardial cells: 16 nCPM
bergmann glia: 14 nCPM
early spermatids: 11 nCPM
brain inhibitory neurons: 11 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 61 nTPM
cerebral cortex: 18 nTPM
white matter: 14 nTPM
basal ganglia: 12 nTPM
amygdala: 11 nTPM
hippocampal formation: 11 nTPM

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS51 as an antibody target. Whether an autoantibody or antibody against PRSS51 could matter depends on whether native PRSS51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS51 is annotated as secreted, so native PRSS51 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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