Seroatlas · Human Serome Atlas

PRSS48

Serine protease 48

Also known as: ESSPL, PRS48_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7RTY5
Gene: PRSS48
Ensembl: ENSG00000189099
Chromosome: 4
Canonical length: 328 aa
Protein class: Enzymes, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q7RTY5|PRSS48
     1  MGPAGCAFTL LLLLGISVCG QPVYSSRVVG GQDAAAGRWP WQVSLHFDHN FICGGSLVSE
    61  RLILTAAHCI QPTWTTFSYT VWLGSITVGD SRKRVKYYVS KIVIHPKYQD TTADVALLKL
   121  SSQVTFTSAI LPICLPSVTK QLAIPPFCWV TGWGKVKESS DRDYHSALQE AEVPIIDRQA
   181  CEQLYNPIGI FLPALEPVIK EDKICAGDTQ NMKDSCKGDS GGPLSCHIDG VWIQTGVVSW
   241  GLECGKSLPG VYTNVIYYQK WINATISRAN NLDFSDFLFP IVLLSLALLR PSCAFGPNTI
   301  HRVGTVAEAV ACIQGWEENA WRFSPRGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS48 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 0.6 nTPM
testis: 0.6 nTPM
skin: 0.3 nTPM
basal ganglia: 0.2 nTPM
amygdala: 0.1 nTPM
cerebral cortex: 0.1 nTPM

Single-cell type

cardiomyocytes: 174 nCPM
paneth cells: 50 nCPM
myonuclei: 48 nCPM
epicardial cells: 46 nCPM
tuft cells: 35 nCPM
salivary myoepithelial cells: 34 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 37 nTPM
pons: 10 nTPM
hypothalamus: 9.5 nTPM
medulla oblongata: 9.1 nTPM
cerebellum: 8.9 nTPM
basal ganglia: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS48 as an antibody target. Whether an autoantibody or antibody against PRSS48 could matter depends on whether native PRSS48 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS48 is annotated as secreted, so native PRSS48 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS48 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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