Seroatlas · Human Serome Atlas

PRSS47P

Putative serine protease 47

Also known as: PRS47_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MTI9
Gene: PRSS47P
Canonical length: 375 aa

OverviewNCBI Gene

No narrative summary is available for PRSS47P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>A8MTI9|PRSS47P
     1  MGYCQGVSQV AVVLLMFPKE KEAFLALAQL LTSKNLPDTV DGQLPMGPHS RASQVAPETT
    61  SSKVDRGVST VCGKPKVVGK IYGGRDAAAG QWPWQASLLY WGSHLCGAVL IDSCWLVSTT
   121  HCFLNKSQAP KNYQVLLGNI QLYHQTQHTQ KMSVHRIITH PDFEKLHPFG SDIAMLQLHL
   181  PMNFTSYIVP VCLPSRDMQL PSNVSCWITG WGMLTEDHKR GPVHTAVPSR LQAVCCSGCR
   241  GQRVGSRVGR FRSMIVHSEG QLRSLMPGDF HLGDSGGPLV CYLPSAWVLV GLASWGLDCR
   301  HPAYPSIFTR VTYFINWIDE IMRLTPLSDP ALAPHTCSPP KPLRAAGLPG PCAALVLPQT
   361  WLLLPLTLRA PWQTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS47P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS47P as an antibody target. Whether an autoantibody or antibody against PRSS47P could matter depends on whether native PRSS47P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS47P is annotated as secreted, so native PRSS47P circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS47P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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