PRSS46P
Putative serine protease 46
Also known as: PRS46_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for PRSS46P in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
174 residues, UniProt reviewed canonical sequence.
>E5RG02|PRSS46P
1 MACGPGDLQS LTSPLSSARL DYQPSIEGPW LRACGQTNVS CRVVKGKLVE VGKWPWQVSI
61 LFLGTYICSG SLIHHQWVLT AAHCLQRFKD LSLYSVMVGV HQRPENSTQL PLTRMVIHKD
121 FSNLMSQDIA LLKLRDSISW SPFVQPVCLP NIKFKPSIGS MCWVIGWGTT GKKGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRSS46P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRSS46P as an antibody target. Whether an autoantibody or antibody against PRSS46P could matter depends on whether native PRSS46P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRSS46P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PRSS46P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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