Seroatlas · Human Serome Atlas

PRSS45P

Putative serine protease 45

Also known as: PRS45_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7RTY3
Gene: PRSS45P
Canonical length: 260 aa

OverviewNCBI Gene

No narrative summary is available for PRSS45P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>Q7RTY3|PRSS45P
     1  MTRHWPWEVS LRMENEHVCG GALIDPSWVV TAAHCIQGTK EYSVVLGTSK LQPMNFSRAL
    61  WVPVRDIIMH PKYWGRAFIM GDVALVHLQT PVTFSEYVQP ICLPEPNFNL KVGTQCWVTG
   121  WSQVKQRFSA NSMLTPELQE AEVFIMDNKR CDRHYKKSFF PPVVPLVLGD MICATNYGEN
   181  LCYGDSGGPL ACEVEGRWIL AGVLSWEKAC VKAQNPGVYT RITKYTKWIK KQMSNGAFSG
   241  PCASACLLFL CWLLQPQMGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS45P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Serine proteases, trypsin domain
Peptidase S1A, chymotrypsin family
Peptidase S1, PA clan
Serine proteases, trypsin family, histidine active site
Trypsin
Serine/Threonine Proteases with Immune and Developmental Roles

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS45P as an antibody target. Whether an autoantibody or antibody against PRSS45P could matter depends on whether native PRSS45P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS45P is annotated as secreted, so native PRSS45P circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS45P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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