Seroatlas · Human Serome Atlas

PRSS42P

Putative serine protease 42

Also known as: PRS42_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5A4
Gene: PRSS42P
Canonical length: 293 aa

OverviewNCBI Gene

No narrative summary is available for PRSS42P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>Q7Z5A4|PRSS42P
     1  MSSGGGSRGL LAWLLLLQPW PGQNWAGMAA PRLPSPLLSE EGGENPEASP APGPEAGPPL
    61  NLFTSFPGDS LLCGRTPLRI VGGVDAEEGR WPWQVSVRTK GRHICGGTLV TATWVLTAGH
   121  CISSRFHYSV KMGDRSVYNE NTSVVVSVQR AFVHPKFSTV TTIRNDLALL QLQHPVNFTS
   181  NIQPICIPQE NFQVEGRTRC WVTGWGKTPE REKLASEILQ DVDQYIMCYE ECNKIIQKAL
   241  SSTKDVIIKG MVCGYKEQGK DSCQGDSGGR LACEYNDTWV QVGIVSWGIG CGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS42P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

serine-type endopeptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS42P as an antibody target. Whether an autoantibody or antibody against PRSS42P could matter depends on whether native PRSS42P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS42P is annotated at the cell surface, where native PRSS42P is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRSS42P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...