Seroatlas · Human Serome Atlas

PRSS41

Serine protease 41

Also known as: PRS41_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7RTY9
Gene: PRSS41
Canonical length: 318 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PRSS41 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q7RTY9|PRSS41
     1  MGARGALLLA LLLARAGLGK PGELGALQAG PGAARRPGGG GREEACGHRE IHALVAGGVE
    61  SARGRWPWQA SLRLRRRHRC GGSLLSRRWV LSAAHCFQKH YYPSEWTVQL GELTSRPTPW
   121  NLRAYSSRYK VQDIIVNPDA LGVLRNDIAL LRLASSVTYN AYIQPICIES STFNFVHRPD
   181  CWVTGWGLIS PSGTPLPPPY NLREAQVTIL NNTRCNYLFE QPSSRSMIWD SMFCAGAEDG
   241  SVDTCKGDSG GPLVCDKDGL WYQVGIVSWG MDCGQPNRPG VYTNISVYFH WIRRVMSHST
   301  PRPNPSQLLL LLALLWAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 1.4 nTPM

Expression across tissuesHPA

Tissue

testis: 1.4 nTPM
salivary gland: 0.5 nTPM
stomach: 0.3 nTPM
fallopian tube: 0.1 nTPM
retina: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

differentiating spermatogonia: 79 nCPM
early primary spermatocytes: 79 nCPM
salivary acinar cells: 15 nCPM
extravillous trophoblasts: 12 nCPM
salivary myoepithelial cells: 5.8 nCPM
lacrimal acinar cells: 5.4 nCPM

Immune cell

eosinophil: 11 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS41 as an antibody target. Whether an autoantibody or antibody against PRSS41 could matter depends on whether native PRSS41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS41 is annotated at the cell surface, where native PRSS41 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRSS41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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